General Structure Information
| PDB ID | 4bfb |
| HGNC Gene Label(s) | BACE2 |
| Structure Name | bace2 xaperone complex |
| Resolution | 2.21Å |
| Reference | AUTH D.W.BANNER,B.GSELL,J.BENZ,J.BERTSCHINGER,D.BURGER,S.BRACK,AUTH 2 S.CUPPULERI,M.DEBULPAEP,A.GAST,D.GRABULOVSKI,M.HENNIG,AUTH 3 H.HILPERT,W.HUBER,A.KUGLSTATTER,E.KUSZNIR,T.LAEREMANS,AUTH 4 H.MATILE,C.MISCENIC,A.RUFER,D.SCHLATTER,J.STEYEART,M.STIHLE,AUTH 5 R.THOMA,M.WEBER,A.RUFTITL MAPPING THE CONFORMATIONAL SPACE ACCESSIBLE TO BACE2 USINGTITL 2 SURFACE MUTANTS AND CO-CRYSTALS WITH FAB-FRAGMENTS,TITL 3 FYNOMERS, AND XAPERONESREF ACTA CRYSTALLOGR.,SECT.D V. 69 1124 2013REFN ISSN 0907-4449PMID 23695257DOI 10.1107/S0907444913006574 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 373 |
| Number Of SNVs | 86 |
| Number Of Permutations | 14535 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.213 |
| p-value | 0.545 |
COSMIC
| Number Of Residues | 373 |
| Number Of SNVs | 3 |
| Number Of Permutations | 153 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.333 |
| p-value | 0.153 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
