Assessment of Structural Intolerance and Durability
General Structure Information 3s8i DDI1 the retroviral-like protease (rvp) domain of human ddi1 1.7Å AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3r0n PVRL2 crystal structure of the immunoglobulin variable domain of nectin-2 1.3Å AUTH D.SAMANTA,U.A.RAMAGOPAL,R.RUBINSTEIN,V.VIGDOROVICH,AUTH 2 S.G.NATHENSON,S.C.ALMOTITL STRUCTURE OF NECTIN-2 REVEALS DETERMINANTS OF HOMOPHILIC ANDTITL 2 HETEROPHILIC INTERACTIONS THAT CONTROL CELL-CELL ADHESION.REF PROC.NATL.ACAD.SCI.USA V. 109 14836 2012REFN ISSN 0027-8424PMID 22927415DOI 10.1073/PNAS.1212912109 Variant Set Distributions Mapped Variants
General Structure Information 1x4v ZFAND2B solution structure of the zf-an1 domain from human hypothetical protein loc130617 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-AN1 DOMAIN FROM HUMANTITL 2 HYPOTHETICAL PROTEIN LOC130617REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lxs CREBBP allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core -1.0Å AUTH S.BRUSCHWEILER,R.KONRAT,M.TOLLINGERTITL ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGHTITL 2 DYNAMIC REPACKING OF THE HYDROPHOBIC CORE.REF ACS CHEM.BIOL. 2013REFN ESSN 1554-8937PMID 23651431DOI 10.1021/CB4002188 Variant Set Distributions Mapped Variants
General Structure Information 1olz SEMA4D the ligand-binding face of the semaphorins revealed by the high resolution crystal structure of sema4d 2.0Å AUTH C.A.LOVE,K.HARLOS,N.MAVADDAT,S.J.DAVIS,D.I.STUART,AUTH 2 E.Y.JONES,R.M.ESNOUFTITL THE LIGAND-BINDING FACE OF THE SEMAPHORINSTITL 2 REVEALED BY THE HIGH-RESOLUTION CRYSTAL STRUCTURETITL 3 OF SEMA4DREF NAT.STRUCT.BIOL. V. 10 843 2003REFN ISSN 1072-8368PMID 12958590DOI 10.1038/NSB977 Variant Set Distributions Ripley’s K […]
General Structure Information 2cto MAEL solution structure of the hmg box like domain from human hypothetical protein flj14904 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 Y.O.KAMATARI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HMG BOX LIKE DOMAIN FROMTITL 2 HUMAN HYPOTHETICAL PROTEIN FLJ14904REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4if6 SIRT1 structure of nad-dependent protein deacetylase sirtuin-1 (closed state, 2.25 a) 2.25Å AUTH A.M.DAVENPORT,F.M.HUBER,A.HOELZTITL STRUCTURE OF A NUCLEOPORIN COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f7o COPS5 crystal structure of csn5 2.6Å AUTH A.ECHALIER,Y.PAN,M.BIROL,N.TAVERNIER,L.PINTARD,F.HOH,C.EBEL,AUTH 2 N.GALOPHE,F.X.CLARET,C.DUMASTITL INSIGHTS INTO THE REGULATION OF THE HUMAN COP9 SIGNALOSOMETITL 2 CATALYTIC SUBUNIT, CSN5/JAB1.REF PROC.NATL.ACAD.SCI.USA V. 110 1273 2013REFN ISSN 0027-8424PMID 23288897DOI 10.1073/PNAS.1209345110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×40 ARAP2 solution structure of the sam domain of human arap2 -1.0Å AUTH A.SASAGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM DOMAIN OF HUMAN ARAP2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gvp AHCYL2 human sahh-like domain of human adenosylhomocysteinase 3 2.25Å AUTH M.I.SIPONEN,M.WISNIEWSKA,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.MOCHE,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.SCHUELERTITL HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 2TITL 2 PROTEIN CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]