Assessment of Structural Intolerance and Durability
General Structure Information 3aqg ZG16B crystal structure of human pancreatic secretory protein zg16b 2.75Å AUTH M.KANAGAWA,T.SATOH,A.IKEDA,Y.NAKANO,H.YAGI,K.KATO,AUTH 2 K.KOJIMA-AIKAWA,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF HUMAN SECRETORY PROTEINS ZG16P ANDTITL 2 ZG16B REVEAL A JACALIN-RELATED BETA-PRISM FOLDREF BIOCHEM.BIOPHYS.RES.COMMUN. 2010REFN ESSN 1090-2104PMID 21110947DOI 10.1016/J.BBRC.2010.11.093 Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC8 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Mapped Variants
General Structure Information 3al2 TOPBP1 crystal structure of topbp1 brct7/8 2.0Å AUTH C.C.LEUNG,Z.GONG,J.CHEN,J.N.GLOVERTITL MOLECULAR BASIS OF BACH1/FANCJ RECOGNITION BY TOPBP1 IN DNATITL 2 REPLICATION CHECKPOINT CONTROLREF J.BIOL.CHEM. V. 286 4292 2011REFN ISSN 0021-9258PMID 21127055DOI 10.1074/JBC.M110.189555 Variant Set Distributions Mapped Variants
General Structure Information 2ziv EME1 crystal structure of the mus81-eme1 complex 2.7Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Mapped Variants
General Structure Information 3cou NUDT16 crystal structure of human nudix motif 16 (nudt16) 1.8Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,C.PERSSON,J.SAGEMARK,H.SCHUELER,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,M.WELIN,J.WEIGELT,AUTH 8 M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bx9 VPS33A human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ecn RNF141 solution structure of the ring domain of the human ring finger protein 141 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 RING FINGER PROTEIN 141REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4akv SNX33 crystal structure of human sorting nexin 33 (snx33) 2.65Å AUTH A.OBERHOLZER,D.S.FROESE,T.KROJER,L.SHRESTHA,AUTH 2 P.FILIPPAKOPOULOS,J.R.C.MUNIZ,F.VON DELFT,C.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,C.BOUNTRA,W.W.YUETITL STRUCTURE OF HUMAN SORTING NEXIN 33REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y6l UBE2E2 human ubiquitin conjugating enzyme e2e2 1.85Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants