Assessment of Structural Intolerance and Durability
General Structure Information 3vpn RRM2 crystal structure of human ribonucleotide reductase subunit m2 (hrrm2) mutant 2.25Å AUTH X.CHEN,Z.XU,H.LIU,L.ZHANG,B.CHEN,L.ZHU,C.YANG,W.ZHU,J.SHAOTITL ESSENTIAL ROLE OF E106 IN THE PROTON-COUPLED ELECTRONTITL 2 TRANSFER IN HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2gl7 CTNNB1 crystal structure of a beta-catenin/bcl9/tcf4 complex 2.6Å AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jod ADCYAP1R1 pac1-rshort n-terminal ec domain pacap(6-38) complex -1.0Å AUTH C.SUN,D.SONG,R.A.DAVIS-TABER,L.W.BARRETT,V.E.SCOTT,AUTH 2 P.L.RICHARDSON,A.PEREDA-LOPEZ,M.E.UCHIC,AUTH 3 L.R.SOLOMON,M.R.LAKE,K.A.WALTER,P.J.HAJDUK,AUTH 4 E.T.OLEJNICZAKTITL SOLUTION STRUCTURE AND MUTATIONAL ANALYSIS OFTITL 2 PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDETITL 3 BINDING TO THE EXTRACELLULAR DOMAIN OF PAC1-RS.REF PROC.NATL.ACAD.SCI.USA V. 104 7875 2007REFN ISSN 0027-8424PMID 17470806DOI 10.1073/PNAS.0611397104 Variant Set Distributions Mapped Variants
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cp5 CLIP1 solution structure of the 1st cap-gly domain in human clip- 170/restin -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CLIP-170/RESTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lot APLNR ar55 solubilised in sds micelles -1.0Å AUTH D.N.LANGELAAN,J.K.RAINEYTITL AR55 SOLUBILISED IN SDS MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 3us4 MATK crystal structure of a sh2 domain of a megakaryocyte-associated tyrosine kinase (matk) from homo sapiens at 1.50 a resolution 1.5Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A SH2 DOMAIN OF ATITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE KINASE (MATK) FROM HOMOTITL 3 SAPIENS […]
General Structure Information 2gwf USP8 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants