Assessment of Structural Intolerance and Durability
General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]
General Structure Information 1mx1 CES1 crystal structure of human liver carboxylesterase in complex with tacrine 2.4Å AUTH S.BENCHARIT,C.L.MORTON,J.L.HYATT,P.KUHN,M.K.DANKS,AUTH 2 P.M.POTTER,M.R.REDINBOTITL CRYSTAL STRUCTURE OF HUMAN CARBOXYLESTERASE 1 COMPLEXED WITHTITL 2 THE ALZHEIMERS DRUG TACRINE: FROM BINDING PROMISCUITY TOTITL 3 SELECTIVE INHIBITIONREF CHEM.BIOL. V. 10 341 2003REFN ISSN 1074-5521PMID 12725862DOI 10.1016/S1074-5521(03)00071-1 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2v9y GART human aminoimidazole ribonucleotide synthetase 2.1Å AUTH M.WELIN,J.G.GROSSMANN,S.FLODIN,T.NYMAN,P.STENMARK,AUTH 2 L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,P.NORDLUND,L.LEHTIOTITL STRUCTURAL STUDIES OF TRI-FUNCTIONAL HUMAN GART.REF NUCLEIC ACIDS RES. V. 38 7308 2010REFN ISSN 0305-1048PMID 20631005DOI 10.1093/NAR/GKQ595 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fs7 CRABP2 crystal structure of apo-cellular retinoic acid binding protein type ii at 1.55 angstroms resolution 1.55Å AUTH S.VAEZESLAMI,E.MATHES,C.VASILEIOU,B.BORHAN,AUTH 2 J.H.GEIGERTITL THE STRUCTURE OF APO-WILD-TYPE CELLULAR RETINOICTITL 2 ACID BINDING PROTEIN II AT 1.4 A AND ITSTITL 3 RELATIONSHIP TO LIGAND BINDING AND NUCLEARTITL 4 TRANSLOCATION.REF J.MOL.BIOL. V. 363 687 2006REFN ISSN […]
General Structure Information 3e4c CASP1 procaspase-1 zymogen domain crystal strucutre 2.05Å AUTH J.M.ELLIOTT,L.ROUGE,C.WIESMANN,J.M.SCHEERTITL CRYSTAL STRUCTURE OF PROCASPASE-1 ZYMOGEN DOMAIN REVEALSTITL 2 INSIGHT INTO INFLAMMATORY CASPASE AUTOACTIVATIONREF J.BIOL.CHEM. V. 284 6546 2009REFN ISSN 0021-9258PMID 19117953DOI 10.1074/JBC.M806121200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants
General Structure Information 2adc PTBP1 solution structure of polypyrimidine tract binding protein rbd34 complexed with cucucu rna -1.0Å AUTH F.C.OBERSTRASS,S.D.AUWETER,M.ERAT,Y.HARGOUS,AUTH 2 A.HENNING,P.WENTER,L.REYMOND,B.AMIR-AHMADY,AUTH 3 S.PITSCH,D.L.BLACK,F.H.T.ALLAINTITL STRUCTURE OF PTB BOUND TO RNA: SPECIFIC BINDINGTITL 2 AND IMPLICATIONS FOR SPLICING REGULATIONREF SCIENCE V. 309 2054 2005REFN ISSN 0036-8075PMID 16179478DOI 10.1126/SCIENCE.1114066 Variant Set Distributions Mapped Variants
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 2qc7 ERP29 crystal structure of the protein-disulfide isomerase related chaperone erp29 2.9Å AUTH N.N.BARAK,P.NEUMANN,M.SEVVANA,M.SCHUTKOWSKI,K.NAUMANN,AUTH 2 M.MALESEVIC,H.REICHARDT,G.FISCHER,M.T.STUBBS,D.M.FERRARITITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN ERP29.REF J.MOL.BIOL. V. 385 1630 2009REFN ISSN 0022-2836PMID 19084538DOI 10.1016/J.JMB.2008.11.052 Variant Set Distributions Mapped Variants
General Structure Information 1nn6 CMA1 human pro-chymase 1.75Å AUTH K.K.REILING,J.KRUCINSKI,L.J.MIERCKE,W.W.RAYMOND,G.H.CAUGHEY,AUTH 2 R.M.STROUDTITL STRUCTURE OF HUMAN PRO-CHYMASE: A MODEL FOR THE ACTIVATINGTITL 2 TRANSITION OF GRANULE-ASSOCIATED PROTEASES.REF BIOCHEMISTRY V. 42 2616 2003REFN ISSN 0006-2960PMID 12614156DOI 10.1021/BI020594D Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants