Assessment of Structural Intolerance and Durability
General Structure Information 4et7 EPHA5 crystal structure of eph receptor 5 2.6Å AUTH J.H.SHI,W.L.ZHU,J.X.SONGTITL CRYSTAL STRUCTURE OF EPH RECEPTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1oip TTPA the molecular basis of vitamin e retention: structure of human alpha-tocopherol transfer protein 1.95Å AUTH R.MEIER,T.TOMIZAKI,C.SCHULZE-BRIESE,U.BAUMANN,AUTH 2 A.STOCKERTITL THE MOLECULAR BASIS OF VITAMIN E RETENTION:TITL 2 STRUCTURE OF HUMAN ALPHA-TOCOPHEROL TRANSFERTITL 3 PROTEINREF J.MOL.BIOL. V. 331 725 2003REFN ISSN 0022-2836PMID 12899840DOI 10.1016/S0022-2836(03)00724-1 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3l82 TERF1 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 1j8i XCL1 solution structure of human lymphotactin -1.0Å AUTH E.S.KULOGLU,D.R.MCCASLIN,M.KITABWALLA,C.D.PAUZA,AUTH 2 J.L.MARKLEY,B.F.VOLKMANTITL MONOMERIC SOLUTION STRUCTURE OF THE PROTOTYPICALTITL 2 C CHEMOKINE LYMPHOTACTIN.REF BIOCHEMISTRY V. 40 12486 2001REFN ISSN 0006-2960PMID 11601972DOI 10.1021/BI011106P Variant Set Distributions Mapped Variants
General Structure Information 2hxs RAB28 crystal structure of rab28a gtpase in the inactive (gdp-3p- bound) form 1.1Å AUTH S.H.LEE,Y.LI,R.DOMINGUEZTITL THE CRYSTAL STRUCTURE OF RAB28 GTPASE IN ACTIVETITL 2 AND INACTIVE FORMSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lqn CRKL solution structure of crkl -1.0Å AUTH W.JANKOWSKI,T.SALEH,M.T.PAI,G.SRIRAM,R.B.BIRGE,C.G.KALODIMOSTITL DOMAIN ORGANIZATION DIFFERENCES EXPLAIN BCR-ABLS PREFERENCETITL 2 FOR CRKL OVER CRKII.REF NAT.CHEM.BIOL. V. 8 590 2012REFN ISSN 1552-4450PMID 22581121DOI 10.1038/NCHEMBIO.954 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tl5 PIK3CG discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer 2.79Å AUTH D.P.SUTHERLIN,L.BAO,M.BERRY,G.CASTANEDO,I.CHUCKOWREE,AUTH 2 J.DOTSON,A.FOLKS,L.FRIEDMAN,R.GOLDSMITH,J.GUNZNER,T.HEFFRON,AUTH 3 J.LESNICK,C.LEWIS,S.MATHIEU,J.MURRAY,J.NONOMIYA,J.PANG,AUTH 4 N.PEGG,W.W.PRIOR,L.ROUGE,L.SALPHATI,D.SAMPATH,Q.TIAN,V.TSUI,AUTH 5 N.C.WAN,S.WANG,B.WEI,C.WIESMANN,P.WU,B.Y.ZHU,A.OLIVEROTITL DISCOVERY OF A POTENT, SELECTIVE, AND ORALLY AVAILABLE CLASSTITL 2 I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K)/MAMMALIAN […]
General Structure Information 1rgo ZFP36L2 structural basis for recognition of the mrna class ii au- rich element by the tandem zinc finger domain of tis11d -1.0Å AUTH B.P.HUDSON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL RECOGNITION OF THE MRNA AU-RICH ELEMENT BY THETITL 2 ZINC FINGER DOMAIN OF TIS11D.REF NAT.STRUCT.MOL.BIOL. V. 11 257 2004REFN ISSN 1545-9993PMID 14981510DOI 10.1038/NSMB738 Variant Set Distributions Ripley’s […]
General Structure Information 1wyp CNN1 solution structure of the ch domain of human calponin 1 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 CALPONIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zr0 TFPI2 crystal structure of kunitz domain 1 of tissue factor pathway inhibitor-2 with bovine trypsin 1.8Å AUTH A.E.SCHMIDT,H.S.CHAND,D.CASCIO,W.KISIEL,S.P.BAJAJTITL CRYSTAL STRUCTURE OF KUNITZ DOMAIN 1 (KD1) OFTITL 2 TISSUE FACTOR PATHWAY INHIBITOR-2 IN COMPLEX WITHTITL 3 TRYPSIN. IMPLICATIONS FOR KD1 SPECIFICITY OFTITL 4 INHIBITIONREF J.BIOL.CHEM. V. 280 27832 2005REFN ISSN 0021-9258PMID 15932872DOI […]