Assessment of Structural Intolerance and Durability
General Structure Information 1w6j LSS structure of human osc in complex with ro 48-8071 2.2Å AUTH R.THOMA,T.SCHULZ-GASCH,B.DARCY,J.BENZ,J.AEBI,AUTH 2 H.DEHMLOW,M.HENNIG,M.STIHLE,A.RUFTITL INSIGHT INTO STEROID SCAFFOLD FORMATION FROM THETITL 2 STRUCTURE OF HUMAN OXIDOSQUALENE CYCLASEREF NATURE V. 432 118 2004REFN ISSN 0028-0836PMID 15525992DOI 10.1038/NATURE02993 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4fsv HSPA2 crystal structure of a heat shock 70kda protein 2 (hspa2) from homo sapiens at 1.80 a resolution 1.8Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A HEAT SHOCK 70KDA PROTEIN 2 (HSPA2)TITL 2 FROM HOMO SAPIENS AT 1.80 A RESOLUTIONREF TO […]
General Structure Information 4fit FHIT fhit-apo 2.5Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t7o GYG1 crystal structure of human glycogenin-1 (gyg1) complexed with manganese, udp-glucose and glucose 1.85Å AUTH A.CHAIKUAD,D.S.FROESE,G.BERRIDGE,F.VON DELFT,U.OPPERMANN,AUTH 2 W.W.YUETITL CONFORMATIONAL PLASTICITY OF GLYCOGENIN AND ITSTITL 2 MALTOSACCHARIDE SUBSTRATE DURING GLYCOGEN BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 108 21028 2011REFN ISSN 0027-8424PMID 22160680DOI 10.1073/PNAS.1113921108 Variant Set Distributions Mapped Variants
General Structure Information 2hgl HNRNPF nmr structure of the first qrrm domain of human hnrnp f -1.0Å AUTH C.DOMINGUEZ,F.H.ALLAINTITL NMR STRUCTURE OF THE THREE QUASI RNA RECOGNITIONTITL 2 MOTIFS (QRRMS) OF HUMAN HNRNP F AND INTERACTIONTITL 3 STUDIES WITH BCL-X G-TRACT RNA: A NOVEL MODE OFTITL 4 RNA RECOGNITION.REF NUCLEIC ACIDS RES. V. 34 3634 […]
General Structure Information 2ea2 METAP2 h-metap2 complexed with a773812 2.5Å AUTH G.T.WANG,R.A.MANTEI,M.KAWAI,J.S.TEDROW,D.M.BARNES,AUTH 2 J.WANG,Q.ZHANG,P.LOU,L.A.GARCIA,J.BOUSKA,M.YATES,AUTH 3 C.PARK,R.A.JUDGE,R.LESNIEWSKI,G.S.SHEPPARD,R.L.BELLTITL LEAD OPTIMIZATION OF METHIONINE AMINOPEPTIDASE-2TITL 2 (METAP2) INHIBITORS CONTAINING SULFONAMIDES OFTITL 3 5,6-DISUBSTITUTED ANTHRANILIC ACIDSREF BIOORG.MED.CHEM.LETT. V. 17 2817 2007REFN ISSN 0960-894XPMID 17350258DOI 10.1016/J.BMCL.2007.02.062 Variant Set Distributions Mapped Variants
General Structure Information 3ddu PREP prolyl oligopeptidase with gsk552 1.56Å AUTH C.D.HAFFNER,C.J.DIAZ,A.B.MILLER,R.A.REID,K.P.MADAUSS,AUTH 2 A.HASSELL,M.H.HANLON,D.J.PORTER,J.D.BECHERER,L.H.CARTERTITL PYRROLIDINYL PYRIDONE AND PYRAZINONE ANALOGUES AS POTENTTITL 2 INHIBITORS OF PROLYL OLIGOPEPTIDASE (POP)REF BIOORG.MED.CHEM.LETT. V. 18 4360 2008REFN ISSN 0960-894XPMID 18606544DOI 10.1016/J.BMCL.2008.06.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2x2r KIF11 crystal structure of human kinesin eg5 in complex with (r)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid 2.2Å AUTH H.Y.K.KAAN,J.WEISS,D.MENGER,V.ULAGANATHAN,K.TKOCZ,C.LAGGNER,AUTH 2 F.POPOWYCZ,B.JOSEPH,F.KOZIELSKITITL STRUCTURE-ACTIVITY RELATIONSHIP AND MULTIDRUG RESISTANCETITL 2 STUDY OF NEW S-TRITYL-L-CYSTEINE DERIVATIVES AS INHIBITORSTITL 3 OF EG5.REF J.MED.CHEM. V. 54 1576 2011REFN ISSN 0022-2623PMID 21344920DOI 10.1021/JM100991M Variant Set Distributions Mapped Variants
General Structure Information 2nzt HK2 crystal structure of human hexokinase ii 2.45Å AUTH W.M.RABEH,H.ZHU,L.NEDYALKOVA,W.TEMPEL,G.WASNEY,AUTH 2 R.LANDRY,M.VEDADI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN HEXOKINASE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ikm POLG crystal structure of human mitochondrial dna polymerase holoenzyme 3.24Å AUTH Y.S.LEE,W.D.KENNEDY,Y.W.YINTITL STRUCTURAL INSIGHT INTO PROCESSIVE HUMANTITL 2 MITOCHONDRIAL DNA SYNTHESIS AND DISEASE-RELATEDTITL 3 POLYMERASE MUTATIONS.REF CELL(CAMBRIDGE,MASS.) V. 139 312 2009REFN ISSN 0092-8674PMID 19837034DOI 10.1016/J.CELL.2009.07.050 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants