Assessment of Structural Intolerance and Durability
General Structure Information 3tsz TJP1 crystal structure of pdz3-sh3-guk core module from human zo-1 in complex with 12mer peptide from human jam-a cytoplasmic tail 2.5Å AUTH J.NOMME,A.S.FANNING,M.CAFFREY,M.F.LYE,J.M.ANDERSON,A.LAVIETITL THE SRC HOMOLOGY 3 DOMAIN IS REQUIRED FOR JUNCTIONALTITL 2 ADHESION MOLECULE BINDING TO THE THIRD PDZ DOMAIN OF THETITL 3 SCAFFOLDING PROTEIN ZO-1.REF J.BIOL.CHEM. V. 286 43352 […]
General Structure Information 2vd5 DMPK structure of human myotonic dystrophy protein kinase in complex with the bisindoylmaleide inhibitor bim viii 2.8Å AUTH J.ELKINS,A.AMOS,F.NIESEN,A.C.W.PIKE,O.FEDOROV,S.KNAPPTITL STRUCTURE OF DYSTROPHIA MYOTONICA PROTEIN KINASE.REF PROTEIN SCI. V. 18 782 2009REFN ISSN 0961-8368PMID 19309729DOI 10.1002/PRO.82 Variant Set Distributions Mapped Variants
General Structure Information 3dm1 CBX3 crystal structure of the complex of human chromobox homolog 3 (cbx3) with peptide 2.4Å AUTH J.RUAN,H.OUYANG,M.F.AMAYA,M.RAVICHANDRAN,P.LOPPNAU,J.MIN,AUTH 2 J.ZANGTITL STRUCTURAL BASIS OF THE CHROMODOMAIN OF CBX3 BOUND TOTITL 2 METHYLATED PEPTIDES FROM HISTONE H1 AND G9A.REF PLOS ONE V. 7 35376 2012REFN ESSN 1932-6203PMID 22514736DOI 10.1371/JOURNAL.PONE.0035376 Variant Set Distributions Mapped Variants
General Structure Information 1uhl NR1H3 crystal structure of the lxralfa-rxrbeta lbd heterodimer 2.9Å AUTH S.SVENSSON,T.OSTBERG,M.JACOBSSON,C.NORSTROM,AUTH 2 K.STEFANSSON,D.HALLEN,I.C.JOHANSSON,K.ZACHRISSON,AUTH 3 D.OGG,L.JENDEBERGTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OFTITL 2 LXRALPHA AND RXRBETA LIGAND-BINDING DOMAINS IN ATITL 3 FULLY AGONISTIC CONFORMATIONREF EMBO J. V. 22 4625 2003REFN ISSN 0261-4189PMID 12970175DOI 10.1093/EMBOJ/CDG456 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4kc3 IL1RL1 cytokine/receptor binary complex 3.27Å AUTH X.LIU,M.HAMMEL,Y.HE,J.A.TAINER,U.S.JENG,L.ZHANG,S.WANG,AUTH 2 X.WANGTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF IL-33 WITH ITSTITL 2 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14918 2013REFN ISSN 0027-8424PMID 23980170DOI 10.1073/PNAS.1308651110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ckr DDR1 crystal structure of the human ddr1 kinase domain in complex with ddr1-in-1 2.2Å AUTH H.KIM,L.TAN,E.L.WEISBERG,F.LIU,P.CANNING,H.G.CHOI,S.A.EZELL,AUTH 2 H.WU,Z.ZHAO,J.WANG,A.MANDINOVA,J.D.GRIFFIN,A.N.BULLOCK,AUTH 3 Q.LIU,S.W.LEE,N.S.GRAYTITL DISCOVERY OF A POTENT AND SELECTIVE DDR1 RECEPTOR TYROSINETITL 2 KINASE INHIBITOR.REF ACS CHEM.BIOL. V. 8 2145 2013REFN ISSN 1554-8929PMID 23899692DOI 10.1021/CB400430T Variant Set Distributions Mapped Variants
General Structure Information 1nlw MXD1 crystal structure of mad-max recognizing dna 2.0Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Mapped Variants
General Structure Information 1gzh TP53BP1 crystal structure of the brct domains of human 53bp1 bound to the p53 tumor supressor 2.6Å AUTH D.J.DERBYSHIRE,B.P.BASU,L.SERPELL,W.JOO,T.DATE,AUTH 2 K.IWABUCHI,A.J.DOHERTYTITL CRYSTAL STRUCTURE OF HUMAN 53BP1 BRCT DOMAINSTITL 2 BOUND TO P53 TUMOUR SUPPRESSORREF EMBO J. V. 21 3863 2002REFN ISSN 0261-4189PMID 12110597DOI 10.1093/EMBOJ/CDF383 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1fqv SKP2 insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex 2.8Å AUTH B.A.SCHULMAN,A.C.CARRANO,P.D.JEFFREY,Z.BOWEN,AUTH 2 E.R.KINNUCAN,M.S.FINNIN,S.J.ELLEDGE,J.W.HARPER,AUTH 3 M.PAGANO,N.P.PAVLETICHTITL INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THETITL 2 STRUCTURE OF THE SKP1-SKP2 COMPLEX.REF NATURE V. 408 381 2000REFN ISSN 0028-0836PMID 11099048DOI 10.1038/35042620 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1d5f UBE3A structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway 2.8Å AUTH L.HUANG,E.KINNUCAN,G.WANG,S.BEAUDENON,P.M.HOWLEY,AUTH 2 J.M.HUIBREGTSE,N.P.PAVLETICHTITL STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTOTITL 2 UBIQUITINATION BY THE E2-E3 ENZYME CASCADE.REF SCIENCE V. 286 1321 1999REFN ISSN 0036-8075PMID 10558980DOI 10.1126/SCIENCE.286.5443.1321 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants