General Structure Information
| PDB ID | 1fqv |
| HGNC Gene Label(s) | SKP2 |
| Structure Name | insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex |
| Resolution | 2.8Å |
| Reference | AUTH B.A.SCHULMAN,A.C.CARRANO,P.D.JEFFREY,Z.BOWEN,AUTH 2 E.R.KINNUCAN,M.S.FINNIN,S.J.ELLEDGE,J.W.HARPER,AUTH 3 M.PAGANO,N.P.PAVLETICHTITL INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THETITL 2 STRUCTURE OF THE SKP1-SKP2 COMPLEX.REF NATURE V. 408 381 2000REFN ISSN 0028-0836PMID 11099048DOI 10.1038/35042620 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 325 |
| Number Of SNVs | 63 |
| Number Of Permutations | 17875 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.085 |
| p-value | 0.866 |
COSMIC
| Number Of Residues | 325 |
| Number Of SNVs | 4 |
| Number Of Permutations | 10 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.021 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 63 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.636 |
| p-value | 0.01 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
