General Structure Information
| PDB ID | 1uhl |
| HGNC Gene Label(s) | NR1H3 |
| Structure Name | crystal structure of the lxralfa-rxrbeta lbd heterodimer |
| Resolution | 2.9Å |
| Reference | AUTH S.SVENSSON,T.OSTBERG,M.JACOBSSON,C.NORSTROM,AUTH 2 K.STEFANSSON,D.HALLEN,I.C.JOHANSSON,K.ZACHRISSON,AUTH 3 D.OGG,L.JENDEBERGTITL CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OFTITL 2 LXRALPHA AND RXRBETA LIGAND-BINDING DOMAINS IN ATITL 3 FULLY AGONISTIC CONFORMATIONREF EMBO J. V. 22 4625 2003REFN ISSN 0261-4189PMID 12970175DOI 10.1093/EMBOJ/CDG456 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 218 |
| Number Of SNVs | 54 |
| Number Of Permutations | 8485 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.28 |
| p-value | 0.167 |
COSMIC
| Number Of Residues | 218 |
| Number Of SNVs | 5 |
| Number Of Permutations | 23 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 0.816 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.288 |
| p-value | 0.615 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
