Assessment of Structural Intolerance and Durability
General Structure Information 2odd RUNX1T1 solution structure of the mynd domain from aml1-eto complexed with smrt, a corepressor -1.0Å AUTH Y.LIU,W.CHEN,J.GAUDET,M.D.CHENEY,L.ROUDAIA,AUTH 2 T.CIERPICKI,R.C.KLET,K.HARTMAN,T.M.LAUE,N.A.SPECK,AUTH 3 J.H.BUSHWELLERTITL STRUCTURAL BASIS FOR RECOGNITION OF SMRT/N-COR BYTITL 2 THE MYND DOMAIN AND ITS CONTRIBUTION TO AML1/ETOSTITL 3 ACTIVITY.REF CANCER CELL V. 11 483 2007REFN ISSN 1535-6108PMID 17560331DOI 10.1016/J.CCR.2007.04.010 Variant Set […]
General Structure Information 2pp4 RUNX1T1 solution structure of eto-tafh refined in explicit solvent -1.0Å AUTH Y.WEI,S.LIU,J.LAUSEN,C.WOODRELL,S.CHO,N.BIRIS,AUTH 2 N.KOBAYASHI,Y.WEI,S.YOKOYAMA,M.H.WERNERTITL A TAF4-HOMOLOGY DOMAIN FROM THE COREPRESSOR ETO ISTITL 2 A DOCKING PLATFORM FOR POSITIVE AND NEGATIVETITL 3 REGULATORS OF TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 14 653 2007REFN ISSN 1545-9993PMID 17572682DOI 10.1038/NSMB1258 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1k2p BTK crystal structure of brutons tyrosine kinase domain 2.1Å AUTH C.MAO,M.ZHOU,F.M.UCKUNTITL CRYSTAL STRUCTURE OF BRUTONS TYROSINE KINASETITL 2 DOMAIN SUGGESTS A NOVEL PATHWAY FOR ACTIVATION ANDTITL 3 PROVIDES INSIGHTS INTO THE MOLECULAR BASIS OFTITL 4 X-LINKED AGAMMAGLOBULINEMIA.REF J.BIOL.CHEM. V. 276 41435 2001REFN ISSN 0021-9258PMID 11527964DOI 10.1074/JBC.M104828200 Variant Set Distributions Ripley’s K […]
General Structure Information 4ag4 DDR1 crystal structure of a ddr1-fab complex 2.8Å AUTH F.CARAFOLI,M.C.MAYER,K.SHIRAISHI,M.A.PECHEVA,L.Y.CHAN,R.NAN,AUTH 2 B.LEITINGER,E.HOHENESTERTITL STRUCTURE OF THE DISCOIDIN DOMAIN RECEPTOR 1 EXTRACELLULARTITL 2 REGION BOUND TO AN INHIBITORY FAB FRAGMENT REVEALS FEATURESTITL 3 IMPORTANT FOR SIGNALING.REF STRUCTURE V. 20 688 2012REFN ISSN 0969-2126PMID 22483115DOI 10.1016/J.STR.2012.02.011 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2vm5 NAIP human bir2 domain of baculoviral inhibitor of apoptosis repeat-containing 1 (birc1) 1.8Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.E.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP ANDTITL 2 CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 4jmk DUSP8 structure of dusp8 1.9Å AUTH D.G.JEONG,C.H.WEI,B.KU,T.J.JEON,P.N.CHIEN,J.K.KIM,S.Y.PARK,AUTH 2 H.S.HWANG,S.Y.RYU,H.PARK,D.S.KIM,S.J.KIM,S.E.RYUTITL THE FAMILY-WIDE STRUCTURE AND FUNCTION OF HUMANTITL 2 DUAL-SPECIFICITY PROTEIN PHOSPHATASESREF ACTA CRYSTALLOGR.,SECT.D V. 70 421 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713029866 Variant Set Distributions Mapped Variants
General Structure Information 3snh DNM1 crystal structure of nucleotide-free human dynamin1 3.7Å AUTH K.FAELBER,Y.POSOR,S.GAO,M.HELD,Y.ROSKE,D.SCHULZE,V.HAUCKE,AUTH 2 F.NOE,O.DAUMKETITL CRYSTAL STRUCTURE OF NUCLEOTIDE-FREE DYNAMIN.REF NATURE V. 477 556 2011REFN ISSN 0028-0836PMID 21927000DOI 10.1038/NATURE10369 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]
General Structure Information 3naf KCNMA1 structure of the intracellular gating ring from the human high- conductance ca2+ gated k+ channel (bk channel) 3.1Å AUTH Y.WU,Y.YANG,S.YE,Y.JIANGTITL STRUCTURE OF THE GATING RING FROM THE HUMANTITL 2 LARGE-CONDUCTANCE CA(2+)-GATED K(+) CHANNEL.REF NATURE V. 466 393 2010REFN ISSN 0028-0836PMID 20574420DOI 10.1038/NATURE09252 Variant Set Distributions Ripley’s K Analysis Plots Variant […]