Assessment of Structural Intolerance and Durability
General Structure Information 1b22 RAD51 rad51 (n-terminal domain) -1.0Å AUTH H.AIHARA,Y.ITO,H.KURUMIZAKA,S.YOKOYAMA,T.SHIBATATITL THE N-TERMINAL DOMAIN OF THE HUMAN RAD51 PROTEINTITL 2 BINDS DNA: STRUCTURE AND A DNA BINDING SURFACE ASTITL 3 REVEALED BY NMR.REF J.MOL.BIOL. V. 290 495 1999REFN ISSN 0022-2836PMID 10390347DOI 10.1006/JMBI.1999.2904 Variant Set Distributions Mapped Variants
General Structure Information 2obh XPC centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants
General Structure Information 1zsx KCNAB2 crystal structure of human potassium channel kv beta-subunit (kcnab2) 1.9Å AUTH P.WENNERSTRAND,I.JOHANNSSON,E.UGOCHUKWU,K.KAVANAGH,AUTH 2 A.EDWARDS,C.ARROWSMITH,L.WILLIAMS,M.SUNDSTROM,K.GUO,AUTH 3 F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNITTITL 2 (KCNAB2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2knx LRP1 solution structure of complement repeat cr17 from lrp-1 -1.0Å AUTH M.GUTTMAN,J.H.PRIETO,T.M.HANDEL,P.J.DOMAILLE,E.A.KOMIVESTITL STRUCTURE OF THE MINIMAL INTERFACE BETWEEN APOE AND LRP.REF J.MOL.BIOL. V. 398 306 2010REFN ISSN 0022-2836PMID 20303980DOI 10.1016/J.JMB.2010.03.022 Variant Set Distributions Mapped Variants
General Structure Information 3f3y SULT2A1 crystal structure of human cytosolic sulfotransferase sult2a1 in complex with pap and lithocholic acid 2.2Å AUTH P.W.PAN,A.DONG,M.AMAYA,A.M.EDWARDSTITL RYSTAL STRUCTURE OF HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASE SULT2A1 IN COMPLEX WITH PAP ANDTITL 3 LITHOCHOLIC ACIDREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2dbj MERTK solution structures of the fn3 domain of human proto- oncogene tyrosine-protein kinase mer precursor -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MERTITL 3 PRECURSORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3vw9 GLO1 human glyoxalase i with an n-hydroxypyridone inhibitor 1.47Å AUTH T.CHIBA,J.OHWADA,H.SAKAMOTO,T.KOBAYASHI,T.A.FUKAMI,M.IRIE,AUTH 2 T.MIURA,K.OHARA,H.KOYANOTITL DESIGN AND EVALUATION OF AZAINDOLE-SUBSTITUTEDTITL 2 N-HYDROXYPYRIDONES AS GLYOXALASE I INHIBITORSREF BIOORG.MED.CHEM.LETT. V. 22 7486 2012REFN ISSN 0960-894XPMID 23122816DOI 10.1016/J.BMCL.2012.10.045 Variant Set Distributions Mapped Variants
General Structure Information 4hot IFIT5 crystal structure of full-length human ifit5 with 5`-triphosphate oligoadenine 2.5Å AUTH Y.M.ABBAS,A.PICHLMAIR,M.W.GORNA,G.SUPERTI-FURGA,B.NAGARTITL STRUCTURAL BASIS FOR VIRAL 5-PPP-RNA RECOGNITION BY HUMANTITL 2 IFIT PROTEINS.REF NATURE V. 494 60 2013REFN ISSN 0028-0836PMID 23334420DOI 10.1038/NATURE11783 Variant Set Distributions Mapped Variants
General Structure Information 1aww BTK sh3 domain from brutons tyrosine kinase, nmr, 42 structures -1.0Å AUTH H.HANSSON,P.T.MATTSSON,P.ALLARD,P.HAAPANIEMI,AUTH 2 M.VIHINEN,C.I.SMITH,T.HARDTITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM BRUTONSTITL 2 TYROSINE KINASE.REF BIOCHEMISTRY V. 37 2912 1998REFN ISSN 0006-2960PMID 9485443DOI 10.1021/BI972409F Variant Set Distributions Mapped Variants
General Structure Information 2ge9 BTK solution structures of the sh2 domain of brutons tyrosine kinase -1.0Å AUTH K.-C.HUANG,H.-T.CHENG,M.-T.PAI,S.-R.TZENG,AUTH 2 J.-W.CHENGTITL SOLUTION STRUCTURE AND PHOSPHOPEPTIDE BINDING OFTITL 2 THE SH2 DOMAIN FROM THE HUMAN BRUTONS TYROSINETITL 3 KINASEREF J.BIOMOL.NMR V. 36 73 2006REFN ISSN 0925-2738PMID 16969585DOI 10.1007/S10858-006-9064-3 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants