4HOT.A | IFIT5

General Structure Information

PDB ID	4hot
HGNC Gene Label(s)	IFIT5
Structure Name	crystal structure of full-length human ifit5 with 5`-triphosphate oligoadenine
Resolution	2.5Å
Reference	AUTH Y.M.ABBAS,A.PICHLMAIR,M.W.GORNA,G.SUPERTI-FURGA,B.NAGARTITL STRUCTURAL BASIS FOR VIRAL 5-PPP-RNA RECOGNITION BY HUMANTITL 2 IFIT PROTEINS.REF NATURE V. 494 60 2013REFN ISSN 0028-0836PMID 23334420DOI 10.1038/NATURE11783

Variant Set Distributions

ExAC Variants

Number Of Residues	476
Number Of SNVs	105
Number Of Permutations	17922
Optimal Distance Threshold	13.0
K Statistic	0.063
p-value	0.085

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:91176975		D>N	A:7	(-11.22, -24.12, 50.59)
10:91176976	rs148414632	D>G	A:7	(-11.22, -24.12, 50.59)
10:91176983		L>F	A:9	(-17.24, -25.97, 53.45)
10:91176987		A>T	A:11	(-16.55, -20.06, 53.22)
10:91176999		E>K	A:15	(-21.62, -17.04, 54.42)
10:91177008		C>R	A:18	(-24.41, -19.30, 64.16)
10:91177045		D>G	A:30	(-16.60, -20.25, 83.87)
10:91177090		L>P	A:45	(-36.02, -19.96, 83.42)
10:91177111		A>D	A:52	(-31.95, -21.49, 72.65)
10:91177128	rs367663038 COSM921276	A>T	A:58	(-23.91, -27.04, 72.09)
10:91177143		L>V	A:63	(-16.20, -23.98, 73.62)
10:91177149		G>R	A:65	(-14.41, -30.44, 73.52)
10:91177152	rs143399526	Q>E	A:66	(-17.46, -31.85, 75.33)
10:91177161		D>Y	A:69	(-21.90, -34.28, 74.33)
10:91177164	COSM1675413	A>T	A:70	(-23.00, -31.16, 71.03)
10:91177165		A>D	A:70	(-23.00, -31.16, 71.03)
10:91177183		Q>R	A:76	(-32.60, -32.80, 72.65)
10:91177194	rs199956643	I>V	A:80	(-37.56, -28.67, 70.94)
10:91177210		H>R	A:85	(-40.98, -24.40, 66.82)
10:91177212		S>P	A:86	(-44.23, -27.83, 63.81)
10:91177227		V>I	A:91	(-37.17, -21.17, 59.76)
10:91177231	rs200757617 COSM921278	R>Q	A:92	(-36.97, -21.30, 63.61)
10:91177251	rs59827270	N>D	A:99	(-24.46, -25.09, 65.53)
10:91177252		N>I	A:99	(-24.46, -25.09, 65.53)
10:91177257		A>T	A:101	(-21.93, -27.73, 60.31)
10:91177277		M>I	A:107	(-15.95, -34.06, 64.24)
10:91177285		L>P	A:110	(-15.78, -32.44, 55.66)
10:91177300		K>R	A:115	(-25.08, -33.70, 54.09)
10:91177301		K>N	A:115	(-25.08, -33.70, 54.09)
10:91177303	rs200078352	Y>C	A:116	(-26.62, -30.53, 58.43)
10:91177320		N>D	A:122	(-32.20, -25.83, 49.98)
10:91177344	COSM3441396	P>S	A:130	(-31.07, -11.33, 50.30)
10:91177350	rs149811101	N>Y	A:132	(-27.06, -17.70, 49.16)
10:91177357	rs145756702	K>M	A:134	(-27.64, -15.01, 55.94)
10:91177381		C>Y	A:142	(-33.69, -13.03, 70.20)
10:91177390		G>A	A:145	(-28.90, -11.75, 72.39)
10:91177396		A>E	A:147	(-25.92, -15.38, 73.70)
10:91177411		G>A	A:152	(-21.06, -10.54, 79.03)
10:91177413		G>R	A:153	(-20.25, -7.26, 79.33)
10:91177420		Y>C	A:155	(-20.10, -10.12, 74.36)
10:91177434		K>E	A:160	(-29.13, -2.65, 72.86)
10:91177438	rs368649132	A>V	A:161	(-28.78, -4.44, 68.88)
10:91177447	rs201301723	E>G	A:164	(-32.34, -2.53, 68.97)
10:91177489		I>N	A:178	(-38.36, -9.86, 78.17)
10:91177516		L>P	A:187	(-26.46, -1.38, 79.85)
10:91177525		S>F	A:190	(-22.97, -1.11, 82.98)
10:91177545		K>E	A:197	(-27.80, 4.49, 84.49)
10:91177560		G>R	A:202	(-39.99, 1.46, 80.32)
10:91177561		G>V	A:202	(-39.99, 1.46, 80.32)
10:91177567		L>W	A:204	(-38.96, -3.13, 82.43)
10:91177587		N>H	A:211	(-45.05, -10.57, 79.64)
10:91177593		D>Y	A:213	(-48.60, -14.55, 83.69)
10:91177594		D>G	A:213	(-48.60, -14.55, 83.69)
10:91177638	rs535431435	V>L	A:228	(-36.18, 5.39, 91.15)
10:91177662		K>E	A:236	(-47.44, -4.47, 96.30)
10:91177663	rs376665939	K>R	A:236	(-47.44, -4.47, 96.30)
10:91177665		Y>H	A:237	(-45.11, -4.33, 91.54)
10:91177666		Y>C	A:237	(-45.11, -4.33, 91.54)
10:91177669		I>T	A:238	(-41.79, -8.14, 95.66)
10:91177690		I>T	A:245	(-44.06, -17.60, 92.81)
10:91177707		V>I	A:251	(-37.82, -14.93, 91.10)
10:91177713	rs556953266	R>C	A:253	(-31.51, -14.66, 91.75)
10:91177714	rs369805092	R>H	A:253	(-31.51, -14.66, 91.75)
10:91177720		A>V	A:255	(-36.27, -10.52, 96.05)
10:91177727		K>N	A:257	(-30.99, -7.28, 94.96)
10:91177734	rs537711619	R>G	A:260	(-29.12, -6.78, 99.80)
10:91177746	rs558900926	S>A	A:264	(-34.42, -6.86, 105.12)
10:91177764	rs200178716 COSM198263	E>K	A:270	(-36.45, -16.43, 104.15)
10:91177789	rs534834408	V>E	A:278	(-33.40, -25.46, 94.03)
10:91177804		S>Y	A:283	(-22.65, -17.46, 91.99)
10:91177834		Y>C	A:293	(-24.28, -13.82, 106.30)
10:91177847		M>I	A:297	(-20.25, -7.53, 110.30)
10:91177870	rs369610086	H>R	A:305	(-18.14, 2.34, 118.99)
10:91177873		N>S	A:306	(-14.90, -0.71, 114.82)
10:91177876		R>I	A:307	(-14.19, -0.70, 120.40)
10:91177894		K>R	A:313	(-15.61, -10.27, 118.58)
10:91177918		S>L	A:321	(-16.80, -17.41, 108.45)
10:91177923		A>S	A:323	(-19.03, -14.56, 104.28)
10:91177924		A>V	A:323	(-19.03, -14.56, 104.28)
10:91177928	rs373762041	I>M	A:324	(-15.32, -16.15, 104.04)
10:91177957	rs137961574	D>G	A:334	(-17.78, -17.67, 88.16)
10:91177963	rs541824745	M>K	A:336	(-14.58, -14.61, 85.02)
10:91177992		N>D	A:346	(-12.26, -7.21, 101.15)
10:91177995	rs142354157	M>V	A:347	(-14.35, -10.52, 104.58)
10:91178008		G>E	A:351	(-10.00, -11.09, 109.57)
10:91178025		A>T	A:357	(-6.08, -11.57, 100.81)
10:91178040	rs139979024	R>W	A:362	(-1.33, -12.27, 94.43)
10:91178052	rs143514329	R>C	A:366	(-2.11, -12.58, 87.05)
10:91178053	rs575185602 COSM4016517	R>H	A:366	(-2.11, -12.58, 87.05)
10:91178070		D>N	A:372	(-11.81, -2.25, 81.55)
10:91178076		H>N	A:374	(-15.50, -5.47, 86.64)
10:91178079	rs545680289	K>Q	A:375	(-9.59, -4.94, 84.88)
10:91178083		H>R	A:376	(-11.84, 0.51, 88.25)
10:91178086	rs201284811	Q>P	A:377	(-13.83, -1.82, 91.24)
10:91178099		H>Q	A:381	(-11.44, -2.80, 96.40)
10:91178106		R>C	A:384	(-9.18, 0.89, 100.64)
10:91178107	rs376725006	R>H	A:384	(-9.18, 0.89, 100.64)
10:91178124	rs528288108	R>C	A:390	(-0.12, -5.73, 103.90)
10:91178127	rs144606657	K>E	A:391	(-0.25, 0.29, 106.75)
10:91178148	rs114336814	H>Y	A:398	(0.89, 0.96, 91.12)
10:91178149	rs371127286	H>R	A:398	(0.89, 0.96, 91.12)
10:91178193	rs186298679	R>C	A:413	(-12.37, 10.83, 88.65)
10:91178194		R>H	A:413	(-12.37, 10.83, 88.65)
10:91178221		K>R	A:422	(-3.66, 11.63, 101.34)
10:91178229		T>A	A:425	(1.50, 15.36, 99.72)
10:91178242		C>Y	A:429	(6.71, 16.17, 103.07)
10:91178248	COSM1254609	N>S	A:431	(11.45, 12.53, 99.37)
10:91178278	rs202194886	L>P	A:441	(0.53, 14.86, 91.87)
10:91178289		Y>H	A:445	(-2.98, 18.23, 89.61)
10:91178311		R>K	A:452	(0.52, 25.17, 85.43)
10:91178320		A>G	A:455	(3.83, 19.90, 83.78)
10:91178322	rs568835542	E>Q	A:456	(4.91, 22.38, 87.15)
10:91178346		I>V	A:464	(14.75, 12.70, 88.89)
10:91178356		E>G	A:467	(14.94, 7.97, 78.72)
10:91178359	rs142594899	N>S	A:468	(10.63, 8.10, 81.65)
10:91178370		L>V	A:472	(9.10, 12.09, 77.37)
10:91178379		L>F	A:475	(5.53, 16.52, 79.03)
10:91178383		C>F	A:476	(4.05, 15.70, 74.66)
10:91178392		R>Q	A:479	(3.54, 21.13, 74.53)