General Structure Information
| PDB ID | 1k2p |
| HGNC Gene Label(s) | BTK |
| Structure Name | crystal structure of brutons tyrosine kinase domain |
| Resolution | 2.1Å |
| Reference | AUTH C.MAO,M.ZHOU,F.M.UCKUNTITL CRYSTAL STRUCTURE OF BRUTONS TYROSINE KINASETITL 2 DOMAIN SUGGESTS A NOVEL PATHWAY FOR ACTIVATION ANDTITL 3 PROVIDES INSIGHTS INTO THE MOLECULAR BASIS OFTITL 4 X-LINKED AGAMMAGLOBULINEMIA.REF J.BIOL.CHEM. V. 276 41435 2001REFN ISSN 0021-9258PMID 11527964DOI 10.1074/JBC.M104828200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 258 |
| Number Of SNVs | 14 |
| Number Of Permutations | 1810 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.066 |
| p-value | 0.095 |
ClinVar
| Number Of Residues | 258 |
| Number Of SNVs | 14 |
| Number Of Permutations | 1827 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.363 |
| p-value | 0.126 |
COSMIC
| Number Of Residues | 258 |
| Number Of SNVs | 4 |
| Number Of Permutations | 145 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.398 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of ClinVar SNVs | 14 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.143 |
| p-value | 0.022 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 14 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.034 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
