Assessment of Structural Intolerance and Durability
General Structure Information 2ax4 PAPSS2 crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 2.5Å AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e4j FCGR3B crystal structure of the soluble human fc-gamma receptor iii 2.5Å AUTH P.SONDERMANN,R.HUBER,V.OOSTHUIZEN,U.JACOBTITL THE 3.2-A CRYSTAL STRUCTURE OF THE HUMAN IGG1 FCTITL 2 FRAGMENT-FC GAMMARIII COMPLEX.REF NATURE V. 406 267 2000REFN ISSN 0028-0836PMID 10917521DOI 10.1038/35018508 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lrq TRIM37 crystal structure of the u-box domain of human ubiquitin- protein ligase (e3), northeast structural genomics consortium target hr4604d. 2.29Å AUTH A.KUZIN,Y.CHEN,J.SEETHARAMAN,M.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,R.SHASTRY,J.K.EVERETT,R.NAIR,AUTH 3 T.B.ACTON,B.ROST,G.T.MONTELIONE,L.TONG,J.F.HUNTTITL E3 UBIQUITIN-PROTEIN LIGASE RING DOMAIN FROM HUMANTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 37 (TRIM37),TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGETTITL 4 HR4604D.REF TO BE PUBLISHEDREFN Variant […]
General Structure Information 1ujs ABLIM3 solution structure of the villin headpiece domain of human actin-binding lim protein homologue (kiaa0843 protein) -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VILLIN HEADPIECE DOMAINTITL 2 OF HUMAN ACTIN-BINDING LIM PROTEIN HOMOLOGUETITL 3 (KIAA0843 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xtc TBL1X structure of the tbl1 tetramerisation domain 2.22Å AUTH J.OBEROI,L.FAIRALL,P.J.WATSON,J.C.YANG,Z.CZIMMERER,AUTH 2 T.KAMPMANN,B.T.GOULT,J.A.GREENWOOD,J.T.GOOCH,AUTH 3 B.C.KALLENBERGER,L.NAGY,D.NEUHAUS,J.W.R.SCHWABETITL STRUCTURAL BASIS FOR THE ASSEMBLY OF THE SMRT/NCOR CORETITL 2 TRANSCRIPTIONAL REPRESSION MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 18 177 2011REFN ISSN 1545-9993PMID 21240272DOI 10.1038/NSMB.1983 Variant Set Distributions Mapped Variants
General Structure Information 2bec CHP2 crystal structure of chp2 in complex with its binding region in nhe1 and insights into the mechanism of ph regulation 2.7Å AUTH Y.BEN AMMAR,S.TAKEDA,T.HISAMITSU,H.MORI,AUTH 2 S.WAKABAYASHITITL CRYSTAL STRUCTURE OF CHP2 COMPLEXED WITHTITL 2 NHE1-CYTOSOLIC REGION AND AN IMPLICATION FOR PHTITL 3 REGULATIONREF EMBO J. V. 25 2315 2006REFN ISSN 0261-4189PMID […]
General Structure Information 2q3e UGDH structure of human udp-glucose dehydrogenase complexed with nadh and udp-glucose 2.0Å AUTH S.EGGER,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANN,B.NIDETZKYTITL STRUCTURE AND MECHANISM OF HUMAN UDP-GLUCOSETITL 2 6-DEHYDROGENASE.REF J.BIOL.CHEM. V. 286 23877 2011REFN ISSN 0021-9258PMID 21502315DOI 10.1074/JBC.M111.234682 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cpt VPS4B solution structure of mit domain from human skd1 -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF MIT DOMAIN FROM HUMAN SKD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p23 ERN1 crystal structure of the human kinase and rnase domains in complex with adp 2.7Å AUTH M.M.ALI,T.BAGRATUNI,E.L.DAVENPORT,P.R.NOWAK,AUTH 2 M.C.SILVA-SANTISTEBAN,A.HARDCASTLE,C.MCANDREWS,M.G.ROWLANDS,AUTH 3 G.J.MORGAN,W.AHERNE,I.COLLINS,F.E.DAVIES,L.H.PEARLTITL STRUCTURE OF THE IRE1 AUTOPHOSPHORYLATION COMPLEX ANDTITL 2 IMPLICATIONS FOR THE UNFOLDED PROTEIN RESPONSE.REF EMBO J. V. 30 894 2011REFN ISSN 0261-4189PMID 21317875DOI 10.1038/EMBOJ.2011.18 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yps SNX3 crystal structure of the px domain of human sorting nexin 3 2.6Å AUTH P.CANNING,D.S.FROESE,T.KROJER,C.STRAIN-DAMERELL,F.VON DELFT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF THE PX DOMAIN OF HUMAN SORTING NEXIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants