Assessment of Structural Intolerance and Durability
General Structure Information 1ohc CDC14B structure of the proline directed phosphatase cdc14 2.5Å AUTH C.H.GRAY,V.M.GOOD,N.K.TONKS,D.BARFORDTITL THE STRUCTURE OF THE CELL CYCLE PROTEIN CDC14TITL 2 REVEALS A PROLINE-DIRECTED PROTEIN PHOSPHATASEREF EMBO J. V. 22 3524 2003REFN ISSN 0261-4189PMID 12853468DOI 10.1093/EMBOJ/CDG348 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n7p RAMP1 crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism 2.8Å AUTH E.TER HAAR,C.M.KOTH,N.ABDUL-MANAN,L.SWENSON,J.T.COLL,AUTH 2 J.A.LIPPKE,C.A.LEPRE,M.GARCIA-GUZMAN,J.M.MOORETITL CRYSTAL STRUCTURE OF THE ECTODOMAIN COMPLEX OF THE CGRPTITL 2 RECEPTOR, A CLASS-B GPCR, REVEALS THE SITE OF DRUGTITL 3 ANTAGONISM.REF STRUCTURE V. 18 1083 […]
General Structure Information 2csw RNF8 solution structure of the fha domain of human ubiquitin ligase protein rnf8 -1.0Å AUTH F.HAYASHI,T.NAGASHIMA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FHA DOMAIN OF HUMANTITL 2 UBIQUITIN LIGASE PROTEIN RNF8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iwn MPDZ 3rd pdz domain of multiple pdz domain protein mpdz (casp target) 1.35Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,AUTH 2 C.PHILLIPS,C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINEDTITL 2 WITH THE HELP OF SELF-BINDING C-TERMINALTITL 3 EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 4j5w NR1I2 crystal structure of the apo-pxr/rxralpha lbd heterotetramer complex 2.8Å AUTH B.D.WALLACE,L.BETTS,G.TALMAGE,R.M.POLLET,N.S.HOLMAN,AUTH 2 M.R.REDINBOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMAN NUCLEARTITL 2 XENOBIOTIC RECEPTOR PXR IN COMPLEX WITH RXRALPHA.REF J.MOL.BIOL. V. 425 2561 2013REFN ISSN 0022-2836PMID 23602807DOI 10.1016/J.JMB.2013.04.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4dhx MCM3AP eny2:ganp complex 2.1Å AUTH D.JANI,S.LUTZ,E.HURT,R.A.LASKEY,M.STEWART,V.O.WICKRAMASINGHETITL FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE MAMMALIANTITL 2 TREX-2 COMPLEX THAT LINKS TRANSCRIPTION WITH NUCLEARTITL 3 MESSENGER RNA EXPORT.REF NUCLEIC ACIDS RES. V. 40 4562 2012REFN ISSN 0305-1048PMID 22307388DOI 10.1093/NAR/GKS059 Variant Set Distributions Mapped Variants
General Structure Information 2iwp MPDZ 12th pdz domain of multiple pdz domain protein mpdz (casp target) 2.15Å AUTH J.M.ELKINS,E.PAPAGRIGORIOU,G.BERRIDGE,X.YANG,C.PHILLIPS,AUTH 2 C.GILEADI,P.SAVITSKY,D.A.DOYLETITL STRUCTURE OF PICK1 AND OTHER PDZ DOMAINS OBTAINED WITH THETITL 2 HELP OF SELF-BINDING C-TERMINAL EXTENSION.REF PROTEIN SCI. V. 16 683 2007REFN ISSN 0961-8368PMID 17384233DOI 10.1110/PS.062657507 Variant Set Distributions Mapped Variants
General Structure Information 2dkx SPDEF solution structure of the sam_pnt-domain of ets transcription factor pdef (prostate ets) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF ETSTITL 2 TRANSCRIPTION FACTOR PDEF (PROSTATE ETS)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dgu SYNCRIP solution structure of the rna binding domain in heterogeneous nuclear ribonucleoprotein q -1.0Å AUTH C.ABE,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN INTITL 2 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN QREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4jxm RRP9 crystal structure of rrp9 wd40 repeats 1.92Å AUTH X.WU,W.TEMPEL,C.XU,M.EL BAKKOURI,H.HE,Y.LI,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF RRP9 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants