Assessment of Structural Intolerance and Durability
General Structure Information 3lyi BRD1 pwwp domain of human bromodomain-containing protein 1 2.1Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wpi F9 factor ixa superactive double mutant 1.99Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rgk MB crystal structure of human myoglobin mutant k45r 1.65Å AUTH S.R.HUBBARD,S.G.LAMBRIGHT,S.G.BOXER,W.A.HENDRICKSONTITL X-RAY CRYSTAL STRUCTURE OF A RECOMBINANT HUMAN MYOGLOBINTITL 2 MUTANT AT 2.8 A RESOLUTIONREF J.MOL.BIOL. V. 20 215 1990REFN ISSN 0022-2836PMID 2342104 Variant Set Distributions Mapped Variants
General Structure Information 3e7c NR3C1 glucocorticoid receptor lbd bound to gsk866 2.15Å AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qdd REG1A crystal structure of human lithostathine to 1.3 a resolution 1.3Å AUTH V.GERBAUD,D.PIGNOL,E.LORET,J.A.BERTRAND,Y.BERLAND,AUTH 2 J.C.FONTECILLA-CAMPS,J.P.CANSELIER,N.GABAS,AUTH 3 J.M.VERDIERTITL MECHANISM OF CALCITE CRYSTAL GROWTH INHIBITION BYTITL 2 THE N-TERMINAL UNDECAPEPTIDE OF LITHOSTATHINE.REF J.BIOL.CHEM. V. 275 1057 2000REFN ISSN 0021-9258PMID 10625646DOI 10.1074/JBC.275.2.1057 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3b2d LY86 crystal structure of human rp105/md-1 complex 2.8Å AUTH U.OHTO,K.MIYAKE,T.SHIMIZUTITL CRYSTAL STRUCTURES OF MOUSE AND HUMAN RP105/MD-1 COMPLEXESTITL 2 REVEAL UNIQUE DIMER ORGANIZATION OF THE TOLL-LIKE RECEPTORTITL 3 FAMILY.REF J.MOL.BIOL. V. 413 815 2011REFN ISSN 0022-2836PMID 21959264DOI 10.1016/J.JMB.2011.09.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1hkf NCR2 the three dimensional structure of nk cell receptor nkp44, a triggering partner in natural cytotoxicity 2.2Å AUTH C.CANTONI,M.PONASSI,R.BIASSONI,R.CONTE,AUTH 2 A.SPALLAROSSA,A.MORETTA,L.MORETTA,M.BOLOGNESI,AUTH 3 D.BORDOTITL THE THREE-DIMENSIONAL STRUCTURE OF THE HUMAN NKTITL 2 CELL RECEPTOR NKP44, A TRIGGERING PARTNER INTITL 3 NATURAL CYTOTOXICITYREF STRUCTURE V. 11 725 2003REFN ISSN 0969-2126PMID 12791260DOI 10.1016/S0969-2126(03)00095-9 Variant […]
General Structure Information 2lp1 APP the solution nmr structure of the transmembrane c-terminal domain of the amyloid precursor protein (c99) -1.0Å AUTH P.J.BARRETT,Y.SONG,W.D.VAN HORN,E.J.HUSTEDT,J.M.SCHAFER,AUTH 2 A.HADZISELIMOVIC,A.J.BEEL,C.R.SANDERSTITL THE AMYLOID PRECURSOR PROTEIN HAS A FLEXIBLE TRANSMEMBRANETITL 2 DOMAIN AND BINDS CHOLESTEROL.REF SCIENCE V. 336 1168 2012REFN ISSN 0036-8075PMID 22654059DOI 10.1126/SCIENCE.1219988 Variant Set Distributions Mapped Variants
General Structure Information 2nn7 CA1 structure of inhibitor binding to carbonic anhydrase i 1.85Å AUTH D.K.SRIVASTAVA,K.M.JUDE,A.L.BANERJEE,M.HALDAR,AUTH 2 S.MANOKARAN,J.KOOREN,S.MALLIK,D.W.CHRISTIANSONTITL STRUCTURAL ANALYSIS OF CHARGE DISCRIMINATION INTITL 2 THE BINDING OF INHIBITORS TO HUMAN CARBONICTITL 3 ANHYDRASES I AND II.REF J.AM.CHEM.SOC. V. 129 5528 2007REFN ISSN 0002-7863PMID 17407288DOI 10.1021/JA068359W Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ou1 APOA2 structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions 2.0Å AUTH M.S.KUMAR,M.CARSON,M.M.HUSSAIN,H.M.K.MURTHYTITL STRUCTURES OF APOLIPOPROTEIN A-II AND A LIPIDTITL 2 SURROGATE COMPLEX PROVIDE INSIGHTS INTOTITL 3 APOLIPOPROTEIN-LIPID INTERACTIONSREF BIOCHEMISTRY V. 41 11681 2002REFN ISSN 0006-2960PMID 12269810DOI 10.1021/BI026069W Variant Set Distributions Mapped Variants