Assessment of Structural Intolerance and Durability
General Structure Information 1hyn SLC4A1 crystal structure of the cytoplasmic domain of human erythrocyte band-3 protein 2.6Å AUTH D.ZHANG,A.KIYATKIN,J.T.BOLIN,P.S.LOWTITL CRYSTALLOGRAPHIC STRUCTURE AND FUNCTIONALTITL 2 INTERPRETATION OF THE CYTOPLASMIC DOMAIN OFTITL 3 ERYTHROCYTE MEMBRANE BAND 3.REF BLOOD V. 96 2925 2000REFN ISSN 0006-4971PMID 11049968 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sdl ISG15 crystal structure of human isg15 in complex with ns1 n-terminal region from influenza b virus, northeast structural genomics consortium target ids hx6481, hr2873, and or2 2.29Å AUTH R.GUAN,L.C.MA,P.G.LEONARD,B.R.AMER,H.SRIDHARAN,C.ZHAO,AUTH 2 R.M.KRUG,G.T.MONTELIONETITL STRUCTURAL BASIS FOR THE SEQUENCE-SPECIFIC RECOGNITION OFTITL 2 HUMAN ISG15 BY THE NS1 PROTEIN OF INFLUENZA B VIRUS.REF PROC.NATL.ACAD.SCI.USA V. […]
General Structure Information 1u5m COL2A1 structure of a chordin-like cysteine-rich repeat (vwc module) from collagen iia -1.0Å AUTH J.M.OLEARY,J.M.HAMILTON,C.M.DEANE,N.V.VALEYEV,AUTH 2 L.J.SANDELL,A.K.DOWNINGTITL SOLUTION STRUCTURE AND DYNAMICS OF A PROTOTYPICALTITL 2 CHORDIN-LIKE CYSTEINE-RICH REPEAT (VON WILLEBRANDTITL 3 FACTOR TYPE C MODULE) FROM COLLAGEN IIAREF J.BIOL.CHEM. V. 279 53857 2004REFN ISSN 0021-9258PMID 15466413DOI 10.1074/JBC.M409225200 Variant Set Distributions Mapped […]
General Structure Information 2p23 FGF19 crystal structure of human fgf19 1.8Å AUTH R.GOETZ,A.BEENKEN,O.A.IBRAHIMI,J.KALININA,AUTH 2 S.K.OLSEN,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,F.ZHANG,AUTH 3 R.J.LINHARDT,X.YU,K.E.WHITE,T.INAGAKI,S.A.KLIEWER,AUTH 4 M.YAMAMOTO,H.KUROSU,Y.OGAWA,M.KURO-O,B.LANSKE,AUTH 5 M.S.RAZZAQUE,M.MOHAMMADITITL MOLECULAR INSIGHTS INTO THE KLOTHO-DEPENDENT,TITL 2 ENDOCRINE MODE OF ACTION OF FIBROBLAST GROWTHTITL 3 FACTOR 19 SUBFAMILY MEMBERS.REF MOL.CELL.BIOL. V. 27 3417 2007REFN ISSN 0270-7306PMID 17339340DOI 10.1128/MCB.02249-06 Variant Set Distributions Mapped Variants
General Structure Information 1hcq ESR1 the crystal structure of the estrogen receptor dna-binding domain bound to dna: how receptors discriminate between their response elements 2.4Å AUTH J.W.SCHWABE,L.CHAPMAN,J.T.FINCH,D.RHODESTITL THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTORTITL 2 DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORSTITL 3 DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS.REF CELL(CAMBRIDGE,MASS.) V. 75 567 1993REFN ISSN 0092-8674PMID […]
General Structure Information 2ggz GUCA1C crystal structure of human guanylate cyclase activating protein-3 3.0Å AUTH R.STEPHEN,K.PALCZEWSKI,M.C.SOUSATITL THE CRYSTAL STRUCTURE OF GCAP3 SUGGESTS MOLECULARTITL 2 MECHANISM OF GCAP-LINKED CONE DYSTROPHIES.REF J.MOL.BIOL. V. 359 266 2006REFN ISSN 0022-2836PMID 16626734DOI 10.1016/J.JMB.2006.03.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1aos ASL human argininosuccinate lyase 4.2Å AUTH M.A.TURNER,A.SIMPSON,R.R.MCINNES,P.L.HOWELLTITL HUMAN ARGININOSUCCINATE LYASE: A STRUCTURAL BASIS FORTITL 2 INTRAGENIC COMPLEMENTATION.REF PROC.NATL.ACAD.SCI.USA V. 94 9063 1997REFN ISSN 0027-8424PMID 9256435DOI 10.1073/PNAS.94.17.9063 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1su3 MMP1 x-ray structure of human prommp-1: new insights into collagenase action 2.2Å AUTH D.JOZIC,G.BOURENKOV,N.H.LIM,R.VISSE,H.NAGASE,AUTH 2 W.BODE,K.MASKOSTITL X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTSTITL 2 INTO PROCOLLAGENASE ACTIVATION AND COLLAGENTITL 3 BINDING.REF J.BIOL.CHEM. V. 280 9578 2005REFN ISSN 0021-9258PMID 15611040DOI 10.1074/JBC.M411084200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ott CD5 crystal structure of cd5_diii 2.5Å AUTH B.RODAMILANS,I.G.MUNOZ,E.BRAGADO-NILSSON,M.R.SARRIAS,AUTH 2 O.PADILLA,F.J.BLANCO,F.LOZANO,G.MONTOYATITL CRYSTAL STRUCTURE OF THE THIRD EXTRACELLULAR DOMAIN OF CD5TITL 2 REVEALS THE FOLD OF A GROUP B SCAVENGER CYSTEINE-RICHTITL 3 RECEPTOR DOMAIN.REF J.BIOL.CHEM. V. 282 12669 2007REFN ISSN 0021-9258PMID 17322294DOI 10.1074/JBC.M611699200 Variant Set Distributions Mapped Variants