Assessment of Structural Intolerance and Durability
General Structure Information 2a01 APOA1 crystal structure of lipid-free human apolipoprotein a-i 2.4Å AUTH A.A.AJEES,G.M.ANANTHARAMAIAH,V.K.MISHRA,AUTH 2 M.M.HUSSAIN,K.H.M.MURTHYTITL CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I:TITL 2 INSIGHTS INTO ITS PROTECTIVE EFFECT AGAINSTTITL 3 CARDIOVASCULAR DISEASES.REF PROC.NATL.ACAD.SCI.USA V. 103 2126 2006REFN ISSN 0027-8424PMID 16452169DOI 10.1073/PNAS.0506877103 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1owa SPTA1 solution structural studies on human erythrocyte alpha spectrin n terminal tetramerization domain -1.0Å AUTH S.PARK,M.S.CAFFREY,M.E.JOHNSON,L.W.FUNGTITL SOLUTION STRUCTURAL STUDIES ON HUMAN ERYTHROCYTETITL 2 ALPHA-SPECTRIN TETRAMERIZATION SITE.REF J.BIOL.CHEM. V. 278 21837 2003REFN ISSN 0021-9258PMID 12672815DOI 10.1074/JBC.M300617200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1shr HBD crystal structure of ferrocyanide bound human hemoglobin a2 at 1.88a resolution 1.88Å AUTH U.SEN,J.DASGUPTA,D.CHOUDHURY,P.DATTA,A.CHAKRABARTI,AUTH 2 S.B.CHAKRABARTY,A.CHAKRABARTY,J.K.DATTAGUPTATITL CRYSTAL STRUCTURES OF HBA2 AND HBE AND MODELING OFTITL 2 HEMOGLOBIN DELTA4: INTERPRETATION OF THE THERMALTITL 3 STABILITY AND THE ANTISICKLING EFFECT OF HBA2 ANDTITL 4 IDENTIFICATION OF THE FERROCYANIDE BINDING SITE INTITL 5 […]
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kv4 EGF egf -1.0Å AUTH H.W.HUANG,S.K.MOHAN,C.YUTITL THE NMR SOLUTION STRUCTURE OF HUMAN EPIDERMAL GROWTH FACTORTITL 2 (HEGF) AT PHYSIOLOGICAL PH AND ITS INTERACTIONS WITH SURAMINREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 402 705 2010REFN ISSN 0006-291XPMID 21029725DOI 10.1016/J.BBRC.2010.10.089 Variant Set Distributions Mapped Variants
General Structure Information 2ifg NTRK1 structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ifg NGF structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2lej PRNP human prion protein mutant huprp(90-231, m129, v210i) -1.0Å AUTH I.BILJAN,G.ILC,G.GIACHIN,A.RASPADORI,I.ZHUKOV,J.PLAVEC,AUTH 2 G.LEGNAMETITL TOWARD THE MOLECULAR BASIS OF INHERITED PRION DISEASES: NMRTITL 2 STRUCTURE OF THE HUMAN PRION PROTEIN WITH V210I MUTATION.REF J.MOL.BIOL. V. 412 660 2011REFN ISSN 0022-2836PMID 21839748DOI 10.1016/J.JMB.2011.07.067 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ila IL1A structure of interleukin 1alpha at 2.7-angstroms resolution 2.3Å AUTH B.J.GRAVES,M.H.HATADA,W.A.HENDRICKSON,J.K.MILLER,AUTH 2 V.S.MADISON,Y.SATOWTITL STRUCTURE OF INTERLEUKIN 1 ALPHA AT 2.7-ATITL 2 RESOLUTION.REF BIOCHEMISTRY V. 29 2679 1990REFN ISSN 0006-2960PMID 2346741DOI 10.1021/BI00463A009 Variant Set Distributions Mapped Variants
General Structure Information 2wnv C1QC complex between c1q globular heads and deoxyribose 1.25Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]