Assessment of Structural Intolerance and Durability
General Structure Information 3ggs PNP human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2-deoxyadenosine 2.52Å AUTH S.AFSHAR,M.R.SAWAYA,S.L.MORRISONTITL STRUCTURE OF A MUTANT HUMAN PURINE NUCLEOSIDE PHOSPHORYLASETITL 2 WITH THE PRODRUG, 2-FLUORO-2-DEOXYADENOSINE AND THETITL 3 CYTOTOXIC DRUG, 2-FLUOROADENINE.REF PROTEIN SCI. V. 18 1107 2009REFN ISSN 0961-8368PMID 19388075DOI 10.1002/PRO.91 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3vi3 ITGB1 crystal structure of alpha5beta1 integrin headpiece (ligand-free form) 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3r8q FN1 structure of fibronectin domain 12-14 2.4Å AUTH N.R.ZACCAI,C.AGNEW,R.L.BRADYTITL STRUCTURE OF FIBRONECTIN DOMAIN 12-14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l7b APOE nmr structure of full length apoe3 -1.0Å AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kq0 ORM1 crystal structure of human alpha1-acid glycoprotein 1.8Å AUTH D.L.SCHONFELD,R.B.RAVELLI,U.MUELLER,A.SKERRATITL THE 1.8-A CRYSTAL STRUCTURE OF ALPHA1-ACIDTITL 2 GLYCOPROTEIN (OROSOMUCOID) SOLVED BY UV RIP REVEALSTITL 3 THE BROAD DRUG-BINDING ACTIVITY OF THIS HUMANTITL 4 PLASMA LIPOCALIN.REF J.MOL.BIOL. V. 384 393 2008REFN ISSN 0022-2836PMID 18823996DOI 10.1016/J.JMB.2008.09.020 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2w08 APCS the structure of serum amyloid p component bound to 0- phospho-threonine 1.7Å AUTH S.E.KOLSTOE,B.H.RIDHA,V.BELLOTTI,N.WANG,AUTH 2 C.V.ROBINSON,S.J.CRUTCH,G.KEIR,R.KUKKASTENVEHMAS,AUTH 3 J.R.GALLIMORE,W.L.HUTCHINSON,P.N.HAWKINS,S.P.WOOD,AUTH 4 M.N.ROSSOR,M.B.PEPYSTITL MOLECULAR DISSECTION OF ALZHEIMERS DISEASETITL 2 NEUROPATHOLOGY BY DEPLETION OF SERUM AMYLOID PTITL 3 COMPONENT.REF PROC.NATL.ACAD.SCI.USA V. 106 7619 2009REFN ISSN 0027-8424PMID 19372378DOI 10.1073/PNAS.0902640106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2voo SSB crystal structure of n-terminal domains of human la protein complexed with rna oligomer uuuuuuuu 1.8Å AUTH O.KOTIK-KOGAN,E.R.VALENTINE,D.SANFELICE,M.R.CONTE,AUTH 2 S.CURRYTITL STRUCTURAL ANALYSIS REVEALS CONFORMATIONALTITL 2 PLASTICITY IN THE RECOGNITION OF RNA 3 ENDS BYTITL 3 THE HUMAN LA PROTEIN.REF STRUCTURE V. 16 852 2008REFN ISSN 0969-2126PMID 18547518DOI 10.1016/J.STR.2008.02.021 Variant Set Distributions […]
General Structure Information 2i1b IL1B crystallographic refinement of interleukin-1 beta at 2.0 angstroms resolution 2.0Å AUTH J.P.PRIESTLE,H.P.SCHAR,M.G.GRUTTERTITL CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN 1 BETATITL 2 AT 2.0 A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 86 9667 1989REFN ISSN 0027-8424PMID 2602367DOI 10.1073/PNAS.86.24.9667 Variant Set Distributions Mapped Variants
General Structure Information 4f27 FGA crystal structures reveal the multi-ligand binding mechanism of the staphylococcus aureus clfb 1.92Å AUTH H.XIANG,Y.FENG,J.W.WANG,B.LIU,Y.G.CHEN,L.LIU,X.M.DENG,AUTH 2 M.J.YANGTITL CRYSTAL STRUCTURES REVEAL THE MULTI-LIGAND BINDING MECHANISMTITL 2 OF STAPHYLOCOCCUS AUREUS CLFBREF PLOS PATHOG. V. 8 02751 2012REFN ISSN 1553-7366PMID 22719251DOI 10.1371/JOURNAL.PPAT.1002751 Variant Set Distributions Mapped Variants
General Structure Information 1jvq SERPINC1 crystal structure at 2.6a of the ternary complex between antithrombin, a p14-p8 reactive loop peptide, and an exogenous tetrapeptide 2.6Å AUTH A.ZHOU,P.E.STEIN,J.A.HUNTINGTON,P.SIVASOTHY,D.A.LOMAS,AUTH 2 R.W.CARRELLTITL HOW SMALL PEPTIDES BLOCK AND REVERSE SERPIN POLYMERISATIONREF J.MOL.BIOL. V. 342 931 2004REFN ISSN 0022-2836PMID 15342247DOI 10.1016/J.JMB.2004.07.078 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]