General Structure Information
| PDB ID | 1jvq |
| HGNC Gene Label(s) | SERPINC1 |
| Structure Name | crystal structure at 2.6a of the ternary complex between antithrombin, a p14-p8 reactive loop peptide, and an exogenous tetrapeptide |
| Resolution | 2.6Å |
| Reference | AUTH A.ZHOU,P.E.STEIN,J.A.HUNTINGTON,P.SIVASOTHY,D.A.LOMAS,AUTH 2 R.W.CARRELLTITL HOW SMALL PEPTIDES BLOCK AND REVERSE SERPIN POLYMERISATIONREF J.MOL.BIOL. V. 342 931 2004REFN ISSN 0022-2836PMID 15342247DOI 10.1016/J.JMB.2004.07.078 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 406 |
| Number Of SNVs | 95 |
| Number Of Permutations | 46195 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.027 |
| p-value | 0.955 |
ClinVar
| Number Of Residues | 406 |
| Number Of SNVs | 18 |
| Number Of Permutations | 9241 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.059 |
| p-value | 0.491 |
COSMIC
| Number Of Residues | 406 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3662 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.429 |
| p-value | 0.166 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 95 |
| Number Of ClinVar SNVs | 18 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.025 |
| p-value | 0.468 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 95 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.129 |
| p-value | 0.584 |