Assessment of Structural Intolerance and Durability
General Structure Information 1xwe C5 nmr structure of c345c (ntr) domain of c5 of complement -1.0Å AUTH J.BRAMHAM,C.-T.THAI,D.C.SOARES,D.UHRIN,R.T.OGATA,AUTH 2 P.N.BARLOWTITL FUNCTIONAL INSIGHTS FROM THE STRUCTURE OF THETITL 2 MULTIFUNCTIONAL C345C DOMAIN OF C5 OF COMPLEMENTREF J.BIOL.CHEM. V. 280 10636 2005REFN ISSN 0021-9258PMID 15598652DOI 10.1074/JBC.M413126200 Variant Set Distributions Mapped Variants
General Structure Information 2ach SERPINA3 crystal structure of cleaved human alpha1-antichymotrypsin at 2.7 angstroms resolution and its comparison with other serpins 2.7Å AUTH U.BAUMANN,R.HUBER,W.BODE,D.GROSSE,M.LESJAK,C.B.LAURELLTITL CRYSTAL STRUCTURE OF CLEAVED HUMAN ALPHA 1-ANTICHYMOTRYPSINTITL 2 AT 2.7 A RESOLUTION AND ITS COMPARISON WITH OTHER SERPINS.REF J.MOL.BIOL. V. 218 595 1991REFN ISSN 0022-2836PMID 2016749DOI 10.1016/0022-2836(91)90704-A Variant Set Distributions Mapped […]
General Structure Information 3umi APP x-ray structure of the e2 domain of the human amyloid precursor protein (app) in complex with zinc 2.4Å AUTH S.O.DAHMS,I.KONNIG,D.ROESER,K.H.GUHRS,M.C.MAYER,D.KADEN,AUTH 2 G.MULTHAUP,M.E.THANTITL METAL BINDING DICTATES CONFORMATION AND FUNCTION OF THETITL 2 AMYLOID PRECURSOR PROTEIN (APP) E2 DOMAIN.REF J.MOL.BIOL. V. 416 438 2012REFN ISSN 0022-2836PMID 22245578DOI 10.1016/J.JMB.2011.12.057 Variant Set Distributions Ripley’s […]
General Structure Information 2v3s OXSR1 structural insights into the recognition of substrates and activators by the osr1 kinase 1.7Å AUTH F.VILLA,J.GOEBEL,F.H.RAFIQI,M.DEAK,J.THASTRUP,AUTH 2 D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURAL INSIGHTS INTO THE RECOGNITION OFTITL 2 SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASEREF EMBO REP. V. 8 839 2007REFN ISSN 1469-3178PMID 17721439DOI 10.1038/SJ.EMBOR.7401048 Variant Set Distributions Mapped Variants
General Structure Information 1uea TIMP1 mmp-3/timp-1 complex 2.8Å AUTH F.X.GOMIS-RUTH,K.MASKOS,M.BETZ,A.BERGNER,R.HUBER,AUTH 2 K.SUZUKI,N.YOSHIDA,H.NAGASE,K.BREW,G.P.BOURENKOV,AUTH 3 H.BARTUNIK,W.BODETITL MECHANISM OF INHIBITION OF THE HUMAN MATRIXTITL 2 METALLOPROTEINASE STROMELYSIN-1 BY TIMP-1.REF NATURE V. 389 77 1997REFN ISSN 0028-0836PMID 9288970DOI 10.1038/37995 Variant Set Distributions Mapped Variants
General Structure Information 2wnu C1QA complex between c1q globular heads and heparan sulfate 2.3Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Mapped Variants
General Structure Information 3mjg PDGFB the structure of a platelet derived growth factor receptor complex 2.3Å AUTH A.H.SHIM,H.LIU,P.J.FOCIA,X.CHEN,P.C.LIN,X.HETITL STRUCTURES OF A PLATELET-DERIVED GROWTH FACTOR/PROPEPTIDETITL 2 COMPLEX AND A PLATELET-DERIVED GROWTH FACTOR/RECEPTORTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 107 11307 2010REFN ISSN 0027-8424PMID 20534510DOI 10.1073/PNAS.1000806107 Variant Set Distributions Mapped Variants
General Structure Information 3iar ADA the crystal structure of human adenosine deaminase 1.52Å AUTH E.UGOCHUKWU,Y.ZHANG,E.HAPKA,W.W.YUE,J.E.BRAY,J.MUNIZ,AUTH 2 N.BURGESS-BROWN,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ADENOSINE DEAMINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lq6 BRD1 solution structure of brd1 phd2 finger -1.0Å AUTH L.LIU,S.QIN,J.ZHANG,P.JI,Y.SHI,J.WUTITL SOLUTION STRUCTURE OF AN ATYPICAL PHD FINGER IN BRPF2 ANDTITL 2 ITS INTERACTION WITH DNAREF J.STRUCT.BIOL. V. 180 165 2012REFN ISSN 1047-8477PMID 22820306DOI 10.1016/J.JSB.2012.06.014 Variant Set Distributions Mapped Variants
General Structure Information 1nl0 F9 crystal structure of human factor ix gla domain in complex of an inhibitory antibody, 10c12 2.2Å AUTH M.HUANG,B.C.FURIE,B.FURIETITL CRYSTAL STRUCTURE OF THE CALCIUM-STABILIZED HUMANTITL 2 FACTOR IX GLA DOMAIN BOUND TO ATITL 3 CONFORMATION-SPECIFIC ANTI-FACTOR IX ANTIBODY.REF J.BIOL.CHEM. V. 279 14338 2004REFN ISSN 0021-9258PMID 14722079DOI 10.1074/JBC.M314011200 Variant Set Distributions Mapped […]