General Structure Information
| PDB ID | 3umi |
| HGNC Gene Label(s) | APP |
| Structure Name | x-ray structure of the e2 domain of the human amyloid precursor protein (app) in complex with zinc |
| Resolution | 2.4Å |
| Reference | AUTH S.O.DAHMS,I.KONNIG,D.ROESER,K.H.GUHRS,M.C.MAYER,D.KADEN,AUTH 2 G.MULTHAUP,M.E.THANTITL METAL BINDING DICTATES CONFORMATION AND FUNCTION OF THETITL 2 AMYLOID PRECURSOR PROTEIN (APP) E2 DOMAIN.REF J.MOL.BIOL. V. 416 438 2012REFN ISSN 0022-2836PMID 22245578DOI 10.1016/J.JMB.2011.12.057 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 183 |
| Number Of SNVs | 43 |
| Number Of Permutations | 16956 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.42 |
COSMIC
| Number Of Residues | 183 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2008 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.667 |
| p-value | 0.751 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.326 |
| p-value | 0.344 |