Assessment of Structural Intolerance and Durability
General Structure Information 3a1f CYBB the crystal structure of nadph binding domain of gp91(phox) 2.0Å AUTH K.HONBOU,N.N.NODA,H.SUMIMOTO,F.INAGAKITITL CRYSTAL STRUCTURE OF NADPH BINDING DOMAIN OFTITL 2 GP91(PHOX)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4aej COL3A1 crystal structure of human fibrillar procollagen type iii c- propeptide trimer 2.21Å AUTH J.M.BOURHIS,N.MARIANO,Y.ZHAO,K.HARLOS,J.EXPOSITO,E.Y.JONES,AUTH 2 C.MOALI,N.AGHAJARI,D.J.S.HULMESTITL STRUCTURAL BASIS OF FIBRILLAR COLLAGEN TRIMERIZATION ANDTITL 2 RELATED GENETIC DISORDERS.REF NAT.STRUCT.MOL.BIOL. V. 19 1031 2012REFN ISSN 1545-9993PMID 23001006DOI 10.1038/NSMB.2389 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3omv RAF1 crystal structure of c-raf (raf-1) 4.0Å AUTH G.HATZIVASSILIOU,K.SONG,I.YEN,B.J.BRANDHUBER,D.J.ANDERSON,AUTH 2 R.ALVARADO,M.J.LUDLAM,D.STOKOE,S.L.GLOOR,G.VIGERS,T.MORALES,AUTH 3 I.ALIAGAS,B.LIU,S.SIDERIS,K.P.HOEFLICH,B.S.JAISWAL,AUTH 4 S.SESHAGIRI,H.KOEPPEN,M.BELVIN,L.S.FRIEDMAN,S.MALEKTITL RAF INHIBITORS PRIME WILD-TYPE RAF TO ACTIVATE THE MAPKTITL 2 PATHWAY AND ENHANCE GROWTH.REF NATURE V. 464 431 2010REFN ISSN 0028-0836PMID 20130576DOI 10.1038/NATURE08833 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cqy PCCA solution structure of b domain from human propionyl-coa carboxylase alpha subunit -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF B DOMAIN FROM HUMANTITL 2 PROPIONYL-COA CARBOXYLASE ALPHA SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c29 VWF crystal structure of high-affinity von willebrand factor a1 domain with disulfide mutation 2.2Å AUTH M.A.BLENNER,X.DONG,T.A.SPRINGERTITL TOWARDS THE STRUCTURAL BASIS OF REGULATION OF VONTITL 2 WILLEBRAND FACTOR BINDING TO GLYCOPROTEIN IBREF J.BIOL.CHEM. V. 289 5565 2014REFN ISSN 0021-9258PMID 24391089DOI 10.1074/JBC.M113.511220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2a55 C4BPA solution structure of the two n-terminal ccp modules of c4b- binding protein (c4bp) alpha-chain. -1.0Å AUTH H.T.JENKINS,L.MARK,G.BALL,J.PERSSON,G.LINDAHL,AUTH 2 D.UHRIN,A.M.BLOM,P.N.BARLOWTITL HUMAN C4B-BINDING PROTEIN, STRUCTURAL BASIS FORTITL 2 INTERACTION WITH STREPTOCOCCAL M PROTEIN, A MAJORTITL 3 BACTERIAL VIRULENCE FACTORREF J.BIOL.CHEM. V. 281 3690 2006REFN ISSN 0021-9258PMID 16330538DOI 10.1074/JBC.M511563200 Variant Set Distributions Mapped […]
General Structure Information 4a5t PLG structural basis for the conformational modulation 3.49Å AUTH Y.XUE,C.BODIN,K.OLSSONTITL CRYSTAL STRUCTURE OF THE NATIVE PLASMINOGEN REVEALS ANTITL 2 ACTIVATION-RESISTANT COMPACT CONFORMATION.REF J. THROMB. HAEMOST. V. 10 1385 2012REFN ISSN 1538-7933PMID 22540246DOI 10.1111/J.1538-7836.2012.04765.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3na0 CYP11A1 crystal structure of human cyp11a1 in complex with 20,22- dihydroxycholesterol 2.5Å AUTH N.STRUSHKEVICH,F.MACKENZIE,T.CHERKESOVA,I.GRABOVEC,S.USANOV,AUTH 2 H.W.PARKTITL STRUCTURAL BASIS FOR PREGNENOLONE BIOSYNTHESIS BY THETITL 2 MITOCHONDRIAL MONOOXYGENASE SYSTEM.REF PROC.NATL.ACAD.SCI.USA V. 108 10139 2011REFN ISSN 0027-8424PMID 21636783DOI 10.1073/PNAS.1019441108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lfi LTF metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1 angstroms resolution 2.1Å AUTH C.A.SMITH,B.F.ANDERSON,H.M.BAKER,E.N.BAKERTITL METAL SUBSTITUTION IN TRANSFERRINS: THE CRYSTAL STRUCTURE OFTITL 2 HUMAN COPPER-LACTOFERRIN AT 2.1-A RESOLUTION.REF BIOCHEMISTRY V. 31 4527 1992REFN ISSN 0006-2960PMID 1581307DOI 10.1021/BI00133A020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3s9d IFNA2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants