Assessment of Structural Intolerance and Durability
General Structure Information 3jyh DPP7 human dipeptidyl peptidase dpp7 2.19Å AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,L.CROMBETT,S.PAGANON,AUTH 2 D.COSSAR,A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,AUTH 3 A.HASSEL,L.SHEWCHUK,A.BOCHKAREVTITL HUMAN DIPEPTIDYL PEPTIDASE DPP7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 2boa CPA4 human procarboxypeptidase a4. 2.2Å AUTH R.GARCIA-CASTELLANOS,R.BONET-FIGUEREDO,I.PALLARES,AUTH 2 S.VENTURA,F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUTHTITL DETAILED MOLECULAR COMPARISON BETWEEN THETITL 2 INHIBITION MODE OF A/B-TYPE CARBOXYPEPTIDASES INTITL 3 THE ZYMOGEN STATE AND BY THE ENDOGENOUS INHIBITORTITL 4 LATEXIN.REF CELL.MOL.LIFE SCI. V. 62 1996 2005REFN ISSN 1420-682XPMID 16091843DOI 10.1007/S00018-005-5174-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3d68 CPB2 crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq) 2.8Å AUTH P.F.MARX,T.H.BRONDIJK,T.PLUG,R.A.ROMIJN,W.HEMRIKA,AUTH 2 J.C.M.MEIJERS,E.G.HUIZINGATITL CRYSTAL STRUCTURES OF TAFI ELUCIDATE THE INACTIVATIONTITL 2 MECHANISM OF ACTIVATED TAFI: A NOVEL MECHANISM FOR ENZYMETITL 3 AUTOREGULATIONREF BLOOD V. 112 2803 2008REFN ISSN 0006-4971PMID 18559974DOI 10.1182/BLOOD-2008-03-146001 Variant Set Distributions Ripley’s K […]
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 1w50 BACE1 apo structure of bace (beta secretase) 1.75Å AUTH S.PATEL,L.VUILLARD,A.CLEASBY,C.W.MURRAY,J.YONTITL APO AND INHIBITOR COMPLEX STRUCTURES OF BACETITL 2 (BETA-SECRETASE)REF J.MOL.BIOL. V. 343 407 2004REFN ISSN 0022-2836PMID 15451669DOI 10.1016/J.JMB.2004.08.018 Variant Set Distributions Mapped Variants
General Structure Information 1w50 BACE1 apo structure of bace (beta secretase) 1.75Å AUTH S.PATEL,L.VUILLARD,A.CLEASBY,C.W.MURRAY,J.YONTITL APO AND INHIBITOR COMPLEX STRUCTURES OF BACETITL 2 (BETA-SECRETASE)REF J.MOL.BIOL. V. 343 407 2004REFN ISSN 0022-2836PMID 15451669DOI 10.1016/J.JMB.2004.08.018 Variant Set Distributions Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants