Assessment of Structural Intolerance and Durability
General Structure Information 2dmd ZFP64 solution structure of the n-terminal c2h2 type zinc-binding domain of the zinc finger protein 64, isoforms 1 and 2 -1.0Å AUTH M.YONEYAMA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL C2H2 TYPETITL 2 ZINC-BINDING DOMAIN OF THE ZINC FINGER PROTEIN 64,TITL 3 ISOFORMS 1 AND 2REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 1x4w ZFAND3 solution structure of the zf-an1 domain from human hypothetical protein flj13222 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-AN1 DOMAIN FROM HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ13222REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d2n MBNL1 crystal structure of mbnl1 tandem zinc finger 1 and 2 domain 2.7Å AUTH M.TEPLOVA,D.J.PATELTITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY THETITL 2 ALTERNATIVE-SPLICING REGULATOR MUSCLEBLIND-LIKETITL 3 MBNL1.REF NAT.STRUCT.MOL.BIOL. V. 15 1343 2008REFN ISSN 1545-9993PMID 19043415DOI 10.1038/NSMB.1519 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2li8 LIN28A the solution structure of the lin28-znf domains bound to aggagau of pre-let-7 mirna -1.0Å AUTH F.E.LOUGHLIN,L.F.GEBERT,H.TOWBIN,A.BRUNSCHWEIGER,J.HALL,AUTH 2 F.H.ALLAINTITL STRUCTURAL BASIS OF PRE-LET-7 MIRNA RECOGNITION BY THE ZINCTITL 2 KNUCKLES OF PLURIPOTENCY FACTOR LIN28.REF NAT.STRUCT.MOL.BIOL. V. 19 84 2011REFN ISSN 1545-9993PMID 22157959DOI 10.1038/NSMB.2202 Variant Set Distributions Mapped Variants
General Structure Information 3toa KAT8 human mof crystal structure with active site lysine partially acetylated 3.0Å AUTH H.YUAN,D.ROSSETTO,H.MELLERT,W.DANG,M.SRINIVASAN,J.JOHNSON,AUTH 2 S.HODAWADEKAR,E.C.DING,K.SPEICHER,N.ABSHIRU,R.PERRY,J.WU,AUTH 3 C.YANG,Y.G.ZHENG,D.W.SPEICHER,P.THIBAULT,A.VERREAULT,AUTH 4 F.B.JOHNSON,S.L.BERGER,R.STERNGLANZ,S.B.MCMAHON,J.COTE,AUTH 5 R.MARMORSTEINTITL MYST PROTEIN ACETYLTRANSFERASE ACTIVITY REQUIRES ACTIVE SITETITL 2 LYSINE AUTOACETYLATION.REF EMBO J. V. 31 58 2011REFN ISSN 0261-4189PMID 22020126DOI 10.1038/EMBOJ.2011.382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2eq3 ZNF347 solution structure of the 17th c2h2 type zinc finger domain of zinc finger protein 347 -1.0Å AUTH K.FUTAMI,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 17TH C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 347REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rlo AGAP2 split ph domain of pi3-kinase enhancer -1.0Å AUTH J.YAN,W.WEN,L.N.CHAN,M.ZHANGTITL SPLIT PLECKSTRIN HOMOLOGY DOMAIN-MEDIATEDTITL 2 CYTOPLASMIC-NUCLEAR LOCALIZATION OF PI3-KINASETITL 3 ENHANCER GTPASEREF J.MOL.BIOL. V. 378 425 2008REFN ISSN 0022-2836PMID 18371979DOI 10.1016/J.JMB.2008.02.052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2djr ZBED2 solution structures of the c2h2 type zinc finger domain of human zinc finger bed domain containing protein 2 -1.0Å AUTH M.SATO,A.SASAGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN ZINC FINGER BED DOMAIN CONTAININGTITL 3 PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]