Assessment of Structural Intolerance and Durability
General Structure Information 3e0l GDA computationally designed ammelide deaminase 2.37Å AUTH P.M.MURPHY,J.M.BOLDUC,J.L.GALLAHER,B.L.STODDARD,AUTH 2 D.BAKERTITL ALTERATION OF ENZYME SPECIFICITY BY COMPUTATIONALTITL 2 LOOP REMODELING AND DESIGN.REF PROC.NATL.ACAD.SCI.USA V. 106 9215 2009REFN ISSN 0027-8424PMID 19470646DOI 10.1073/PNAS.0811070106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 2psx KLK5 crystal structure of human kallikrein 5 in complex with leupeptin 2.3Å AUTH M.DEBELA,P.GOETTIG,V.MAGDOLEN,R.HUBER,N.M.SCHECHTER,W.BODETITL STRUCTURAL BASIS OF THE ZINC INHIBITION OF HUMAN TISSUETITL 2 KALLIKREIN 5.REF J.MOL.BIOL. V. 373 1017 2007REFN ISSN 0022-2836PMID 17881000DOI 10.1016/J.JMB.2007.08.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hcs TRAF6 crystal structure of the n-terminal domain of traf6 2.2Å AUTH Q.YIN,S.C.LIN,B.LAMOTHE,M.LU,Y.C.LO,G.HURA,L.ZHENG,AUTH 2 R.L.RICH,A.D.CAMPOS,D.G.MYSZKA,M.J.LENARDO,AUTH 3 B.G.DARNAY,H.WUTITL E2 INTERACTION AND DIMERIZATION IN THE CRYSTALTITL 2 STRUCTURE OF TRAF6.REF NAT.STRUCT.MOL.BIOL. V. 16 658 2009REFN ISSN 1545-9993PMID 19465916DOI 10.1038/NSMB.1605 Variant Set Distributions Mapped Variants
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2ecb ZHX1 the solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein -1.0Å AUTH S.OHNISHI,N.TOCHIO,A.SASAGAWA,K.SAITO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIRD HOMEOBOXTITL 2 DOMAIN OF HUMAN ZINC FINGERS AND HOMEOBOXES PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3kv4 PHF8 structure of phf8 in complex with histone h3 2.19Å AUTH J.R.HORTON,A.K.UPADHYAY,H.H.QI,X.ZHANG,Y.SHI,AUTH 2 X.CHENGTITL ENZYMATIC AND STRUCTURAL INSIGHTS FOR SUBSTRATETITL 2 SPECIFICITY OF A FAMILY OF JUMONJI HISTONE LYSINETITL 3 DEMETHYLASES.REF NAT.STRUCT.MOL.BIOL. V. 17 38 2010REFN ISSN 1545-9993PMID 20023638DOI 10.1038/NSMB.1753 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4lu3 CA14 the crystal structure of the human carbonic anhydrase xiv 2.0Å AUTH V.ALTERIO,P.PAN,S.PARKKILA,M.BUONANNO,C.T.SUPURAN,S.M.MONTI,AUTH 2 G.DE SIMONETITL THE STRUCTURAL COMPARISON BETWEEN MEMBRANE-ASSOCIATED HUMANTITL 2 CARBONIC ANHYDRASES PROVIDES INSIGHTS INTO DRUG DESIGN OFTITL 3 SELECTIVE INHIBITORS.REF BIOPOLYMERS V. 101 769 2014REFN ISSN 0006-3525PMID 24374484DOI 10.1002/BIP.22456 Variant Set Distributions Mapped Variants
General Structure Information 2das ZMYM5 solution structure of trash domain of zinc finger mym-type protein 5 -1.0Å AUTH T.N.NIRAULA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF TRASH DOMAIN OF ZINC FINGERTITL 2 MYM-TYPE PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2mkd ZNF346 human jaz zf3 residues 168-227 -1.0Å AUTH R.G.BURGE,M.A.MARTINEZ-YAMOUT,H.J.DYSON,P.E.WRIGHTTITL STRUCTURAL CHARACTERIZATION OF INTERACTIONS BETWEEN THETITL 2 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN JAZ ANDTITL 3 NUCLEIC ACIDS.REF BIOCHEMISTRY V. 53 1495 2014REFN ISSN 0006-2960PMID 24521053DOI 10.1021/BI401675H Variant Set Distributions Mapped Variants