Assessment of Structural Intolerance and Durability
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 2c7a PGR structure of the progesterone receptor-dna complex 2.5Å AUTH S.C.ROEMER,D.C.DONHAM,L.SHERMAN,V.H.PON,AUTH 2 D.P.EDWARDS,M.E.A.CHURCHILLTITL STRUCTURE OF THE PROGESTERONE RECEPTOR-TITL 2 DEOXYRIBONUCLEIC ACID COMPLEX: NOVEL INTERACTIONSTITL 3 REQUIRED FOR BINDING TO HALF-SITE RESPONSETITL 4 ELEMENTS.REF MOL.ENDOCRINOL. V. 20 3042 2006REFN ISSN 0888-8809PMID 16931575DOI 10.1210/ME.2005-0511 Variant Set Distributions Mapped Variants
General Structure Information 3d24 ESRRA crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha) 2.11Å AUTH H.GRESCHIK,M.ALTHAGE,R.FLAIG,Y.SATO,V.CHAVANT,AUTH 2 C.PELUSO-ILTIS,L.CHOULIER,P.CRONET,N.ROCHEL,AUTH 3 R.SCHULE,P.E.STROMSTEDT,D.MORASTITL COMMUNICATION BETWEEN THE ERR{ALPHA} HOMODIMERTITL 2 INTERFACE AND THE PGC-1{ALPHA} BINDING SURFACE VIATITL 3 THE HELIX 8-9 LOOP.REF J.BIOL.CHEM. V. […]
General Structure Information 2uzp PRKCG crystal structure of the c2 domain of human protein kinase c gamma. 2.0Å AUTH A.C.W.PIKE,A.AMOS,C.JOHANSSON,F.SOBOTT,P.SAVITSKY,AUTH 2 G.BERRIDGE,O.FEDOROV,C.UMEANO,F.GORREC,G.BUNKOCZI,AUTH 3 J.DEBRECZENI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF C2 DOMAIN OF PROTEIN KINASE C GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e7c NR3C1 glucocorticoid receptor lbd bound to gsk866 2.15Å AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kci HERC2 the third rld domain of herc2 1.8Å AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lrq TRIM37 crystal structure of the u-box domain of human ubiquitin- protein ligase (e3), northeast structural genomics consortium target hr4604d. 2.29Å AUTH A.KUZIN,Y.CHEN,J.SEETHARAMAN,M.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,R.SHASTRY,J.K.EVERETT,R.NAIR,AUTH 3 T.B.ACTON,B.ROST,G.T.MONTELIONE,L.TONG,J.F.HUNTTITL E3 UBIQUITIN-PROTEIN LIGASE RING DOMAIN FROM HUMANTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 37 (TRIM37),TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGETTITL 4 HR4604D.REF TO BE PUBLISHEDREFN Variant […]