General Structure Information 2yho UBE2D1 the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2k6g RFC1 solution structure of the dna binding brct domain from the large subunit of human replication factor c -1.0Å AUTH M.KOBAYASHI,E.AB,A.M.J.J.BONVIN,G.SIEGALTITL SOLUTION STRUCTURE OF THE DNA BOUND BRCT DOMAINTITL 2 FROM HUMAN REPLICATION FACTOR C P140REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2jxj KDM5A nmr structure of the arid domain from the histone h3k4 demethylase rbp2 -1.0Å AUTH S.TU,Y.C.TENG,C.YUAN,Y.T.WU,M.Y.CHAN,A.N.CHENG,AUTH 2 P.H.LIN,L.J.JUAN,M.D.TSAITITL THE ARID DOMAIN OF THE H3K4 DEMETHYLASE RBP2 BINDSTITL 2 TO A DNA CCGCCC MOTIFREF NAT.STRUCT.MOL.BIOL. V. 15 419 2008REFN ISSN 1545-9993PMID 18270511DOI 10.1038/NSMB.1400 Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ky9 VAV1 autoinhibited vav1 2.73Å AUTH B.YU,I.R.MARTINS,P.LI,G.K.AMARASINGHE,J.UMETANI,AUTH 2 M.E.FERNANDEZ-ZAPICO,D.D.BILLADEAU,M.MACHIUS,D.R.TOMCHICK,AUTH 3 M.K.ROSENTITL STRUCTURAL AND ENERGETIC MECHANISMS OF COOPERATIVETITL 2 AUTOINHIBITION AND ACTIVATION OF VAV1REF CELL(CAMBRIDGE,MASS.) V. 140 246 2010REFN ISSN 0092-8674PMID 20141838DOI 10.1016/J.CELL.2009.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ror VAV1 solution structure of the vav1 sh2 domain complexed with a tyrosine-phosphorylated peptide from slp76 -1.0Å AUTH T.KASAI,M.TANAKA,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VAV1 SH2 DOMAINTITL 2 COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDETITL 3 FROM SLP76REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants