General Structure Information 2z5d UBE2H human ubiquitin-conjugating enzyme e2 h 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL.CELL PROTEOMICS V. 11 329 2012REFN ISSN 1535-9476PMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2lxp UBE2G2 nmr structure of two domains in ubiquitin ligase gp78, ring and g2br, bound to its conjugating enzyme ube2g -1.0Å AUTH R.DAS,Y.H.LIANG,J.MARIANO,J.LI,T.HUANG,A.KING,S.G.TARASOV,AUTH 2 A.M.WEISSMAN,X.JI,R.A.BYRDTITL ALLOSTERIC REGULATION OF E2:E3 INTERACTIONS PROMOTE ATITL 2 PROCESSIVE UBIQUITINATION MACHINE.REF EMBO J. V. 32 2504 2013REFN ISSN 0261-4189PMID 23942235DOI 10.1038/EMBOJ.2013.174 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3phd UBA52 crystal structure of human hdac6 in complex with ubiquitin 3.0Å AUTH H.OUYANG,Y.O.ALI,M.RAVICHANDRAN,A.DONG,W.QIU,F.MACKENZIE,AUTH 2 S.DHE-PAGANON,C.H.ARROWSMITH,R.G.ZHAITITL PROTEIN AGGREGATES ARE RECRUITED TO AGGRESOME BY HISTONETITL 2 DEACETYLASE 6 VIA UNANCHORED UBIQUITIN C TERMINI.REF J.BIOL.CHEM. V. 287 2317 2012REFN ISSN 0021-9258PMID 22069321DOI 10.1074/JBC.M111.273730 Variant Set Distributions Mapped Variants
General Structure Information 2m3o NEDD4 structure and dynamics of a human nedd4 ww domain-enac complex -1.0Å AUTH R.BOBBY,K.MEDINI,P.NEUDECKER,T.V.LEE,M.A.BRIMBLE,AUTH 2 F.J.MCDONALD,J.S.LOTT,A.J.DINGLEYTITL STRUCTURE AND DYNAMICS OF HUMAN NEDD4-1 WW3 IN COMPLEX WITHTITL 2 THE ALPHA ENAC PY MOTIF.REF BIOCHIM.BIOPHYS.ACTA V.1834 1632 2013REFN ISSN 0006-3002PMID 23665454DOI 10.1016/J.BBAPAP.2013.04.031 Variant Set Distributions Mapped Variants
General Structure Information 3bzh UBE2E1 crystal structure of human ubiquitin-conjugating enzyme e2 e1 1.6Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2grr RANGAP1 crystal structure of human rangap1-ubc9-d127s 1.3Å AUTH A.A.YUNUS,C.D.LIMATITL LYSINE ACTIVATION AND FUNCTIONAL ANALYSIS OFTITL 2 E2-MEDIATED CONJUGATION IN THE SUMO PATHWAY.REF NAT.STRUCT.MOL.BIOL. V. 13 491 2006REFN ISSN 1545-9993PMID 16732283DOI 10.1038/NSMB1104 Variant Set Distributions Mapped Variants
General Structure Information 3rpg BMI1 bmi1/ring1b-ubch5c complex structure 2.65Å AUTH M.L.BENTLEY,J.E.CORN,K.C.DONG,Q.PHUNG,T.K.CHEUNG,A.G.COCHRANTITL RECOGNITION OF UBCH5C AND THE NUCLEOSOME BY THE BMI1/RING1BTITL 2 UBIQUITIN LIGASE COMPLEX.REF EMBO J. V. 30 3285 2011REFN ISSN 0261-4189PMID 21772249DOI 10.1038/EMBOJ.2011.243 Variant Set Distributions Mapped Variants
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 1jm7 BRCA1 solution structure of the brca1/bard1 ring-domain heterodimer -1.0Å AUTH P.S.BRZOVIC,P.RAJAGOPAL,D.W.HOYT,M.C.KING,AUTH 2 R.E.KLEVITTITL STRUCTURE OF A BRCA1-BARD1 HETERODIMERIC RING-RINGTITL 2 COMPLEX.REF NAT.STRUCT.BIOL. V. 8 833 2001REFN ISSN 1072-8368PMID 11573085DOI 10.1038/NSB1001-833 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zjd TNFAIP3 a20 otu domain in reduced, active state at 1.87 a resolution 1.87Å AUTH Y.KULATHU,F.J.GARCIA,T.E.T.MEVISSEN,M.BUSCH,N.ARNAUDO,AUTH 2 K.S.CARROLL,D.BARFORD,D.KOMANDERTITL REGULATION OF A20 AND OTHER OTU DEUBIQUITINASES BYTITL 2 REVERSIBLE OXIDATIONREF NAT.COMMUN. V. 4 1569 2013REFN ISSN 2041-1723PMID 23463012DOI 10.1038/NCOMMS2567 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]