3LCO.A | CSF1R

General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]

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2FGI.A | FGFR1

General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]

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3G0F.B | KIT

General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]

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3A4O.X | LYN

General Structure Information 3a4o LYN lyn kinase domain 3.0Å AUTH N.MIYANO,T.KINOSHITA,R.NAKAI,Y.KIRII,K.YOKOTA,AUTH 2 T.TADATITL STRUCTURAL BASIS FOR THE INHIBITOR RECOGNITION OFTITL 2 HUMAN LYN KINASE DOMAINREF BIOORG.MED.CHEM.LETT. V. 19 6557 2009REFN ISSN 0960-894XPMID 19857964DOI 10.1016/J.BMCL.2009.10.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2C0O.B | HCK

General Structure Information 2c0o HCK src family kinase hck with bound inhibitor a-770041 2.85Å AUTH A.BURCHAT,D.W.BORHANI,D.J.CALDERWOOD,G.C.HIRST,B.LI,AUTH 2 R.F.STACHLEWITZTITL DISCOVERY OF A-770041, A SRC-FAMILY SELECTIVE ORALLY ACTIVETITL 2 LCK INHIBITOR THAT PREVENTS ORGAN ALLOGRAFT REJECTION.REF BIOORG.MED.CHEM.LETT. V. 16 118 2006REFN ISSN 0960-894XPMID 16216497DOI 10.1016/J.BMCL.2005.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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2ZM1.A | LCK

General Structure Information 2zm1 LCK crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394) 2.1Å AUTH T.OZAWA,E.TSUJI,M.OZAWA,C.HANDA,H.MUKAIYAMA,AUTH 2 T.NISHIMURA,S.KOBAYASHI,K.OKAZAKITITL THE IMPORTANCE OF CH/PI HYDROGEN BONDS IN RATIONALTITL 2 DRUG DESIGN: AN AB INITIO FRAGMENT MOLECULARTITL 3 ORBITAL STUDY TO LEUKOCYTE-SPECIFIC PROTEINTITL 4 TYROSINE (LCK) KINASEREF BIOORG.MED.CHEM. V. […]

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3RCD.A | ERBB2

General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]

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2JWA.A | ERBB2

General Structure Information 2jwa ERBB2 erbb2 transmembrane segment dimer spatial structure -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,P.E.VOLYNSKY,Y.S.ERMOLYUK,AUTH 2 E.N.TKACH,A.G.SOBOL,V.V.CHUPIN,M.P.KIRPICHNIKOV,AUTH 3 R.G.EFREMOV,A.S.ARSENIEVTITL SPATIAL STRUCTURE OF THE DIMERIC TRANSMEMBRANETITL 2 DOMAIN OF THE GROWTH FACTOR RECEPTOR ERBB2TITL 3 PRESUMABLY CORRESPONDING TO THE RECEPTOR ACTIVETITL 4 STATEREF J.BIOL.CHEM. V. 283 6950 2008REFN ISSN 0021-9258PMID 18178548DOI 10.1074/JBC.M709202200 Variant Set Distributions Ripley’s K […]

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3BE1.A | ERBB2

General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]

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2WO3.B | EFNA2

General Structure Information 2wo3 EFNA2 crystal structure of the epha4-ephrina2 complex 2.35Å AUTH T.A.BOWDEN,A.R.ARICESCU,J.E.NETTLESHIP,C.SIEBOLD,AUTH 2 N.RAHMAN-HUQ,R.J.OWENS,D.I.STUART,E.Y.JONESTITL STRUCTURAL PLASTICITY OF EPH-RECEPTOR A4 FACILITATESTITL 2 CROSS-CLASS EPHRIN SIGNALLINGREF STRUCTURE V. 17 1386 2009REFN ISSN 0969-2126PMID 19836338DOI 10.1016/J.STR.2009.07.018 Variant Set Distributions Mapped Variants

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