Assessment of Structural Intolerance and Durability
General Structure Information 2pfi CLCNKA crystal structure of the cytoplasmic domain of the human chloride channel clc-ka 1.6Å AUTH S.MARKOVIC,R.DUTZLERTITL THE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THETITL 2 CHLORIDE CHANNEL CLC-KA REVEALS A CONSERVEDTITL 3 INTERACTION INTERFACE.REF STRUCTURE V. 15 715 2007REFN ISSN 0969-2126PMID 17562318DOI 10.1016/J.STR.2007.04.013 Variant Set Distributions Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 1xke RANBP2 solution structure of the second ran-binding domain from human ranbp2 -1.0Å AUTH J.P.GEYER,R.DOKER,W.KREMER,X.ZHAO,J.KUHLMANN,AUTH 2 H.R.KALBITZERTITL SOLUTION STRUCTURE OF THE RAN-BINDING DOMAIN 2 OFTITL 2 RANBP2 AND ITS INTERACTION WITH THE C TERMINUS OFTITL 3 RAN.REF J.MOL.BIOL. V. 348 711 2005REFN ISSN 0022-2836PMID 15826666DOI 10.1016/J.JMB.2005.02.033 Variant Set Distributions Mapped Variants
General Structure Information 2c0m PEX5 apo form of the tpr domain of the pex5p receptor 2.5Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 1qgk KPNA2 structure of importin beta bound to the ibb domain of importin alpha 2.5Å AUTH G.CINGOLANI,C.PETOSA,K.WEIS,C.W.MULLERTITL STRUCTURE OF IMPORTIN-BETA BOUND TO THE IBB DOMAINTITL 2 OF IMPORTIN-ALPHA.REF NATURE V. 399 221 1999REFN ISSN 0028-0836PMID 10353244DOI 10.1038/20367 Variant Set Distributions Mapped Variants
General Structure Information 3p0l STAR human steroidogenic acute regulatory protein 3.4Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4efg RBP2 crystal structure of the q108k:k40l:t51v:t53c:y19w:r58w:t29l mutant of cellular retinol binding protein type ii in complex with all-trans- retinal at 1.58 angstrom resolution 1.58Å AUTH W.WANG,Z.NOSSONI,T.BERBASOVA,C.T.WATSON,I.YAPICI,K.S.LEE,AUTH 2 C.VASILEIOU,J.H.GEIGER,B.BORHANTITL TUNING THE ELECTRONIC ABSORPTION OF PROTEIN-EMBEDDEDTITL 2 ALL-TRANS-RETINAL.REF SCIENCE V. 338 1340 2012REFN ISSN 0036-8075PMID 23224553DOI 10.1126/SCIENCE.1226135 Variant Set Distributions Mapped Variants
General Structure Information 1oip TTPA the molecular basis of vitamin e retention: structure of human alpha-tocopherol transfer protein 1.95Å AUTH R.MEIER,T.TOMIZAKI,C.SCHULZE-BRIESE,U.BAUMANN,AUTH 2 A.STOCKERTITL THE MOLECULAR BASIS OF VITAMIN E RETENTION:TITL 2 STRUCTURE OF HUMAN ALPHA-TOCOPHEROL TRANSFERTITL 3 PROTEINREF J.MOL.BIOL. V. 331 725 2003REFN ISSN 0022-2836PMID 12899840DOI 10.1016/S0022-2836(03)00724-1 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4gky LMAN1 crystal structure of a carbohydrate-binding domain 2.42Å AUTH C.ZHENG,R.C.PAGE,V.DAS,J.C.NIX,E.WIGREN,S.MISRA,B.ZHANGTITL STRUCTURAL CHARACTERIZATION OF CARBOHYDRATE BINDING BY LMAN1TITL 2 PROTEIN PROVIDES NEW INSIGHT INTO THE ENDOPLASMIC RETICULUMTITL 3 EXPORT OF FACTORS V (FV) AND VIII (FVIII).REF J.BIOL.CHEM. V. 288 20499 2013REFN ISSN 0021-9258PMID 23709226DOI 10.1074/JBC.M113.461434 Variant Set Distributions Mapped Variants
General Structure Information 3eh2 SEC24C crystal structure of the human copii-coat protein sec24c 2.35Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants