Assessment of Structural Intolerance and Durability
General Structure Information 3cuq VPS36 integrated structural and functional model of the human escrt-ii complex 2.61Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants
General Structure Information 3tw8 DENND1B gef domain of dennd 1b in complex with rab gtpase rab35 2.1Å AUTH X.WU,M.J.BRADLEY,Y.CAI,D.KUMMEL,E.M.DE LA CRUZ,F.A.BARR,AUTH 2 K.M.REINISCHTITL INSIGHTS REGARDING GUANINE NUCLEOTIDE EXCHANGE FROM THETITL 2 STRUCTURE OF A DENN-DOMAIN PROTEIN COMPLEXED WITH ITS RABTITL 3 GTPASE SUBSTRATE.REF PROC.NATL.ACAD.SCI.USA V. 108 18672 2011REFN ISSN 0027-8424PMID 22065758DOI 10.1073/PNAS.1110415108 Variant Set Distributions […]
General Structure Information 2y5c FDX1L structure of human ferredoxin 2 (fdx2)in complex with 2fe2s cluster 1.7Å AUTH H.WEBERT,A.HOBLER,A.D.SHEFTEL,S.MOLIK,M.MAESTRE-REYNA,AUTH 2 L.-O.ESSEN,D.VORNISCESCU,M.KEUSGEN,F.HANNEMANN,R.BERNHARDT,AUTH 3 R.LILLTITL STRUCTURE AND FUNCTIONAL STUDIES ON HUMAN MITOCHONDRIALTITL 2 FERREDOXINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ekg FXN mature human frataxin 1.8Å AUTH S.DHE-PAGANON,R.SHIGETA,Y.I.CHI,M.RISTOW,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF HUMAN FRATAXIN.REF J.BIOL.CHEM. V. 275 30753 2000REFN ISSN 0021-9258PMID 10900192DOI 10.1074/JBC.C000407200 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c0a IQSEC1 arf1(delta1-17)in complex with brag2 sec7-ph domain 3.3Å AUTH K.AIZEL,V.BIOU,J.NAVAZA,L.V.DUARTE,V.CAMPANACCI,J.CHERFILS,AUTH 2 M.ZEGHOUFTITL INTEGRATED CONFORMATIONAL AND LIPID-SENSING REGULATION OFTITL 2 ENDOSOMAL ARFGEF BRAG2.REF PLOS BIOL. V. 11 01652 2013REFN ISSN 1544-9173PMID 24058294DOI 10.1371/JOURNAL.PBIO.1001652 Variant Set Distributions Mapped Variants
General Structure Information 3lra LIN7C structural basis for assembling a human tripartite complex dlg1-mpp7- mals3 2.95Å AUTH X.YANG,X.XIE,L.CHEN,H.ZHOU,Z.WANG,W.ZHAO,R.TIAN,R.ZHANG,AUTH 2 C.TIAN,J.LONG,Y.SHENTITL STRUCTURAL BASIS FOR TANDEM L27 DOMAIN-MEDIATEDTITL 2 POLYMERIZATIONREF FASEB J. V. 24 4806 2010REFN ISSN 0892-6638PMID 20702775DOI 10.1096/FJ.10-163857 Variant Set Distributions Mapped Variants
General Structure Information 4kbs GLTPD1 crystal structure of human ceramide-1-phosphate transfer protein (cptp) in complex with 12:0 phosphatidic acid (12:0 pa) 1.9Å AUTH D.K.SIMANSHU,R.K.KAMLEKAR,D.S.WIJESINGHE,X.ZOU,X.ZHAI,AUTH 2 S.K.MISHRA,J.G.MOLOTKOVSKY,L.MALININA,E.H.HINCHCLIFFE,AUTH 3 C.E.CHALFANT,R.E.BROWN,D.J.PATELTITL NON-VESICULAR TRAFFICKING BY A CERAMIDE-1-PHOSPHATE TRANSFERTITL 2 PROTEIN REGULATES EICOSANOIDS.REF NATURE V. 500 463 2013REFN ISSN 0028-0836PMID 23863933DOI 10.1038/NATURE12332 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3swy CNGA3 cnga3 626-672 containing clz domain 1.9Å AUTH N.G.SHUART,Y.HAITIN,S.S.CAMP,K.D.BLACK,W.N.ZAGOTTATITL MOLECULAR MECHANISM FOR 3:1 SUBUNIT STOICHIOMETRY OF RODTITL 2 CYCLIC NUCLEOTIDE-GATED ION CHANNELS.REF NAT COMMUN V. 2 457 2011REFN ESSN 2041-1723PMID 21878911DOI 10.1038/NCOMMS1466 Variant Set Distributions Mapped Variants
General Structure Information 2il1 RAB12 crystal structure of a predicted human gtpase in complex with gdp 2.1Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF A PREDICTED HUMAN GTPASE IN COMPLEXTITL 2 WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3e1r CEP55 midbody targeting of the escrt machinery by a non-canonical coiled-coil in cep55 2.0Å AUTH H.H.LEE,N.ELIA,R.GHIRLANDO,J.LIPPINCOTT-SCHWARTZ,AUTH 2 J.H.HURLEYTITL MIDBODY TARGETING OF THE ESCRT MACHINERY BY ATITL 2 NONCANONICAL COILED COIL IN CEP55.REF SCIENCE V. 322 576 2008REFN ISSN 0036-8075PMID 18948538DOI 10.1126/SCIENCE.1162042 Variant Set Distributions Mapped Variants