Assessment of Structural Intolerance and Durability
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 3bd9 HS3ST5 human 3-o-sulfotransferase isoform 5 with bound pap 2.3Å AUTH D.XU,A.F.MOON,D.SONG,L.C.PEDERSEN,J.LIUTITL ENGINEERING SULFOTRANSFERASES TO MODIFY HEPARANTITL 2 SULFATE.REF NAT.CHEM.BIOL. V. 4 200 2008REFN ISSN 1552-4450PMID 18223645DOI 10.1038/NCHEMBIO.66 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wqz NLGN4X crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3.9Å AUTH I.P.FABRICHNY,P.LEONE,G.SULZENBACHER,D.COMOLETTI,M.T.MILLER,AUTH 2 P.TAYLOR,Y.BOURNE,P.MARCHOTTITL STRUCTURAL ANALYSIS OF THE SYNAPTIC PROTEIN NEUROLIGIN ANDTITL 2 ITS BETA-NEUREXIN COMPLEX: DETERMINANTS FOR FOLDING ANDTITL 3 CELL ADHESION.REF NEURON V. 56 979 2007REFN ISSN 0896-6273PMID 18093521DOI 10.1016/J.NEURON.2007.11.013 Variant Set Distributions Ripley’s […]
General Structure Information 3cyn GPX8 the structure of human gpx8 2.0Å AUTH K.L.KAVANAGH,C.JOHANSSON,W.W.YUE,G.KOCHAN,U.OPPERMANNTITL THE STRUCTURE OF HUMAN GPX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3icu RNF128 protease-associated domain of the e3 ligase grail 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL PA DOMAIN OF THE E3 LIGASE GRAILREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dgc IL22RA1 structure of il-22/il-22r1 2.5Å AUTH B.C.JONES,N.J.LOGSDON,M.R.WALTERTITL STRUCTURE OF IL-22 BOUND TO ITS HIGH-AFFINITY IL-22R1 CHAIN.REF STRUCTURE V. 16 1333 2008REFN ISSN 0969-2126PMID 18599299DOI 10.1016/J.STR.2008.06.005 Variant Set Distributions Mapped Variants
General Structure Information 3eu9 ZDHHC17 the ankyrin repeat domain of huntingtin interacting protein 14 1.99Å AUTH T.GAO,R.E.COLLINS,J.R.HORTON,X.ZHANG,R.ZHANG,A.DHAYALAN,AUTH 2 R.TAMAS,A.JELTSCH,X.CHENGTITL THE ANKYRIN REPEAT DOMAIN OF HUNTINGTIN INTERACTING PROTEINTITL 2 14 CONTAINS A SURFACE AROMATIC CAGE, A POTENTIAL SITE FORTITL 3 METHYL-LYSINE BINDING.REF PROTEINS V. 76 772 2009REFN ISSN 0887-3585PMID 19434754DOI 10.1002/PROT.22452 Variant Set Distributions Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants