Assessment of Structural Intolerance and Durability
General Structure Information 3fn3 CD274 dimeric structure of pd-l1 2.7Å AUTH Y.CHEN,P.LIU,F.GAO,H.CHENG,J.QI,G.F.GAOTITL A DIMERIC STRUCTURE OF PD-L1: FUNCTIONAL UNITS ORTITL 2 EVOLUTIONARY RELICS?REF PROTEIN CELL V. 1 153 2010REFN ISSN 1674-800XPMID 21203985DOI 10.1007/S13238-010-0022-1 Variant Set Distributions Mapped Variants
General Structure Information 3b94 TNFSF18 crystal structure of human gitrl 2.5Å AUTH X.M.SONG,Z.C.ZHOU,M.I.GREENETITL CRYSTAL STRUCTURE OF HUMAN GITRLREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2kdb HERPUD2 solution structure of human ubiquitin-like domain of herpud2_9_85, northeast structural genomics consortium (nesg) target ht53a -1.0Å AUTH R.DOHERTY,B.WU,C.FARES,A.LEMAK,A.GUTMANAS,A.SEMESI,A.YEE,AUTH 2 C.H.ARROWSMITH,S.DHE-PAGANONTITL STRUCTURE OF HUMAN HOMOCYSTEINE-INDUCIBLE, ENDOPLASMICTITL 2 RETICULUM STRESS-INDUCIBLE, UBIQUITIN-LIKE DOMAIN MEMBER 2TITL 3 (HERPUD2 OR HERP)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2kav SCN2A solution structure of the human voltage-gated sodium channel, brain isoform (nav1.2) -1.0Å AUTH V.Z.MILOUSHEV,J.A.LEVINE,M.A.ARBING,J.F.HUNT,G.S.PITT,AUTH 2 A.G.PALMERTITL SOLUTION STRUCTURE OF THE NAV1.2 C-TERMINAL EF-HAND DOMAIN.REF J.BIOL.CHEM. V. 284 6446 2009REFN ISSN 0021-9258PMID 19129176DOI 10.1074/JBC.M807401200 Variant Set Distributions Mapped Variants
General Structure Information 2j67 TLR10 the tir domain of human toll-like receptor 10 (tlr10) 2.2Å AUTH T.NYMAN,P.STENMARK,S.FLODIN,I.JOHANSSON,M.HAMMARSTROM,AUTH 2 P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF THE HUMAN TOLL-LIKE RECEPTOR 10TITL 2 CYTOPLASMIC DOMAIN REVEALS A PUTATIVE SIGNALING DIMER.REF J.BIOL.CHEM. V. 283 11861 2008REFN ISSN 0021-9258PMID 18332149DOI 10.1074/JBC.C800001200 Variant Set Distributions Mapped Variants
General Structure Information 1ncu TTN titin module m5, n-terminally extended, nmr -1.0Å AUTH M.PFUHL,S.IMPROTA,A.S.POLITOUS,A.PASTORETITL WHEN A MODULE IS ALSO A DOMAIN: THE ROLE OF THE NTITL 2 TERMINUS IN THE STABILITY AND THE DYNAMICS OFTITL 3 IMMUNOGLOBULIN DOMAINS FROM TITIN.REF J.MOL.BIOL. V. 265 242 1997REFN ISSN 0022-2836PMID 9020985DOI 10.1006/JMBI.1996.0725 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3a2a HVCN1 the structure of the carboxyl-terminal domain of the human voltage- gated proton channel hv1 2.0Å AUTH S.J.LI,Q.ZHAO,Q.ZHOU,H.UNNO,Y.ZHAI,F.SUNTITL THE ROLE AND STRUCTURE OF THE CARBOXYL-TERMINAL DOMAIN OFTITL 2 THE HUMAN VOLTAGE-GATED PROTON CHANNEL HV1.REF J.BIOL.CHEM. V. 285 12047 2010REFN ISSN 0021-9258PMID 20147290DOI 10.1074/JBC.M109.040360 Variant Set Distributions Mapped Variants
General Structure Information 4hti PTPRN2 crystallographic structure of the membrane-proximal ectodomain of the human receptor-type protein-tyrosine phosphatase phogrin 1.95Å AUTH M.E.NOGUERA,M.E.PRIMO,J.JAKONCIC,E.POSKUS,M.SOLIMENA,AUTH 2 M.R.ERMACORATITL X-RAY STRUCTURE OF THE MATURE ECTODOMAIN OF PHOGRIN.REF J.STRUCT.FUNCT.GENOM. V. 16 1 2015REFN ISSN 1345-711XPMID 25421040DOI 10.1007/S10969-014-9191-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants