Assessment of Structural Intolerance and Durability
General Structure Information 3fd5 SEPHS1 crystal structure of human selenophosphate synthetase 1 complex with ampcp 1.9Å AUTH K.T.WANG,J.WANG,L.F.LI,X.D.SUTITL CRYSTAL STRUCTURES OF CATALYTIC INTERMEDIATES OFTITL 2 HUMAN SELENOPHOSPHATE SYNTHETASE 1.REF J.MOL.BIOL. V. 390 747 2009REFN ISSN 0022-2836PMID 19477186DOI 10.1016/J.JMB.2009.05.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hlz KHK crystal structure of human ketohexokinase (casp target) 1.85Å AUTH W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN KETOHEXOKINASE (CASPTITL 2 TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4jg7 RPS6KA3 structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide 3.0Å AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ys2 BMX solution structure of the btk motif of human cytoplasmic tyrosine-protein kinase bmx -1.0Å AUTH H.ABE,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,M.YONEYAMA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BTK MOTIF OF HUMANTITL 2 CYTOPLASMIC TYROSINE-PROTEIN KINASE BMXREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2le3 CPT1A n-terminal regulatory segment of carnitine palmitoyltransferase 1a -1.0Å AUTH J.N.RAO,G.Z.WARREN,S.ESTOLT-POVEDANO,V.A.ZAMMIT,T.S.ULMERTITL AN ENVIRONMENT-DEPENDENT STRUCTURAL SWITCH UNDERLIES THETITL 2 REGULATION OF CARNITINE PALMITOYLTRANSFERASE 1A.REF J.BIOL.CHEM. V. 286 42545 2011REFN ISSN 0021-9258PMID 21990363DOI 10.1074/JBC.M111.306951 Variant Set Distributions Mapped Variants
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 4n3b HCFC1 crystal structure of human o-glcnac transferase bound to a peptide from hcf-1 pro-repeat2(1-26)e10q and udp-5sglcnac 2.17Å AUTH M.B.LAZARUS,J.JIANG,V.KAPURIA,T.BHUIYAN,J.JANETZKO,AUTH 2 W.F.ZANDBERG,D.J.VOCADLO,W.HERR,S.WALKERTITL HCF-1 IS CLEAVED IN THE ACTIVE SITE OF O-GLCNAC TRANSFERASE.REF SCIENCE V. 342 1235 2013REFN ISSN 0036-8075PMID 24311690DOI 10.1126/SCIENCE.1243990 Variant Set Distributions Mapped Variants
General Structure Information 2eao EPHB1 solution structure of the c-terminal sam-domain of mouse ephrin type-b receptor 1 precursor (ec 2.7.1.112) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL SAM-DOMAIN OFTITL 2 MOUSE EPHRIN TYPE-B RECEPTOR 1 PRECURSOR (ECTITL 3 2.7.1.112)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1av5 HINT1 pkci-substrate analog 2.0Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Mapped Variants
General Structure Information 3zfx EPHB1 crystal structure of ephb1 2.5Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants