General Structure Information 4g34 EIF2AK3 crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution 2.7Å AUTH J.M.AXTEN,J.R.MEDINA,Y.FENG,A.SHU,S.P.ROMERIL,S.W.GRANT,AUTH 2 W.H.LI,D.A.HEERDING,E.MINTHORN,T.MENCKEN,C.ATKINS,Q.LIU,AUTH 3 S.RABINDRAN,R.KUMAR,X.HONG,A.GOETZ,T.STANLEY,J.D.TAYLOR,AUTH 4 S.D.SIGETHY,G.H.TOMBERLIN,A.M.HASSELL,K.M.KAHLER,AUTH 5 L.M.SHEWCHUK,R.T.GAMPETITL DISCOVERY OFTITL 2 7-METHYL-5-(1-{[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}-2,3-TITL 3 DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINETITL 4 (GSK2606414), A POTENT AND SELECTIVE FIRST-IN-CLASSTITL 5 INHIBITOR OF PROTEIN KINASE R (PKR)-LIKE ENDOPLASMICTITL 6 RETICULUM KINASE […]
General Structure Information 4ks7 PAK6 pak6 kinase domain in complex with pf-3758309 1.4Å AUTH J.GAO,B.H.HA,H.J.LOU,E.M.MORSE,R.ZHANG,D.A.CALDERWOOD,AUTH 2 B.E.TURK,T.J.BOGGONTITL SUBSTRATE AND INHIBITOR SPECIFICITY OF THE TYPE IITITL 2 P21-ACTIVATED KINASE, PAK6.REF PLOS ONE V. 8 77818 2013REFN ESSN 1932-6203PMID 24204982DOI 10.1371/JOURNAL.PONE.0077818 Variant Set Distributions Mapped Variants
General Structure Information 4dlj MAPK14 human p38 map kinase in complex with rl163 2.6Å AUTH M.GETLIK,J.R.SIMARD,M.TERMATHE,C.GRUTTER,M.RABILLER,AUTH 2 W.A.VAN OTTERLO,D.RAUHTITL FLUOROPHORE LABELED KINASE DETECTS LIGANDS THAT BIND WITHINTITL 2 THE MAPK INSERT OF P38ALPHA KINASE.REF PLOS ONE V. 7 39713 2012REFN ESSN 1932-6203PMID 22768308DOI 10.1371/JOURNAL.PONE.0039713 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4k8a PTK2 fragment-based discovery of focal adhesion kinase inhibitors 2.91Å AUTH U.GRADLER,J.BOMKE,D.MUSIL,V.DRESING,M.LEHMANN,G.HOLZEMANN,AUTH 2 H.GREINER,C.ESDAR,M.KRIER,T.HEINRICHTITL FRAGMENT-BASED DISCOVERY OF FOCAL ADHESION KINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 5401 2013REFN ISSN 0960-894XPMID 23973211DOI 10.1016/J.BMCL.2013.07.050 Variant Set Distributions Mapped Variants
General Structure Information 4hab PLK1 crystal structure of plk1 polo-box domain in complex with pl-49 2.65Å AUTH R.N.MURUGAN,J.E.PARK,D.LIM,M.AHN,C.CHEONG,T.KWON,K.Y.NAM,AUTH 2 S.H.CHOI,B.Y.KIM,D.Y.YOON,M.B.YAFFE,D.Y.YU,K.S.LEE,J.K.BANGTITL DEVELOPMENT OF CYCLIC PEPTOMER INHIBITORS TARGETING THETITL 2 POLO-BOX DOMAIN OF POLO-LIKE KINASE 1.REF BIOORG.MED.CHEM. V. 21 2623 2013REFN ISSN 0968-0896PMID 23498919DOI 10.1016/J.BMC.2013.02.020 Variant Set Distributions Mapped Variants
General Structure Information 4jg7 RPS6KA3 structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide 3.0Å AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4mle GCK human glucokinase in complex with novel amino thiazole activator 2.6Å AUTH R.J.HINKLIN,S.A.BOYD,M.J.CHICARELLI,K.R.CONDROSKI,AUTH 2 W.E.DEWOLF,P.A.LEE,W.LEE,A.SINGH,L.THOMAS,W.C.VOEGTLI,AUTH 3 L.WILLIAMS,T.D.AICHERTITL IDENTIFICATION OF A NEW CLASS OF GLUCOKINASE ACTIVATORSTITL 2 THROUGH STRUCTURE-BASED DESIGN.REF J.MED.CHEM. V. 56 7669 2013REFN ISSN 0022-2623PMID 24015910DOI 10.1021/JM401116K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]