Assessment of Structural Intolerance and Durability
General Structure Information 2ene ZNF347 solution structure of the c2h2 type zinc finger (region 592- 624) of human zinc finger protein 347 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 592-624) OF HUMAN ZINC FINGER PROTEIN 347REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3oln UHRF2 crystal structure of the sra domain of e3 ubiquitin-protein ligase uhrf2 2.3Å AUTH J.R.WALKER,S.XUE,G.V.AVVAKUMOV,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE SET AND RING ASSOCIATED (SRA) DOMAIN OF HUMANTITL 2 UBIQUITIN-LIKE CONTAINING PHD AND RING FINGER DOMAINS 2TITL 3 (UHRF2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ohv BACH2 crystal structure of the human bach2 poz domain, form ii 2.2Å AUTH G.O.ROSBROOK,M.A.STEAD,S.B.CARR,S.C.WRIGHTTITL THE STRUCTURE OF THE BACH2 POZ-DOMAIN DIMER REVEALS ANTITL 2 INTERSUBUNIT DISULFIDE BOND.REF ACTA CRYSTALLOGR.,SECT.D V. 68 26 2012REFN ISSN 0907-4449PMID 22194330DOI 10.1107/S0907444911048335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2yy0 MYCBP crystal structure of ms0802, c-myc-1 binding protein domain from homo sapiens 2.4Å AUTH Y.XIE,H.WANG,IHSANAWATI,S.KISHISHITA,C.TAKEMOTO,AUTH 2 K.MURAYAMA,M.SHIROZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF C-MYC-1 BINDING PROTEINTITL 2 DOMAIN FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l9s PHF12 solution structure of pf1 sid1-msin3a pah2 complex -1.0Å AUTH G.S.KUMAR,T.XIE,Y.ZHANG,I.RADHAKRISHNANTITL SOLUTION STRUCTURE OF THE MSIN3A PAH2-PF1 SID1 COMPLEX: ATITL 2 MAD1/MXD1-LIKE INTERACTION DISRUPTED BY MRG15 IN THETITL 3 RPD3S/SIN3S COMPLEX.REF J.MOL.BIOL. V. 408 987 2011REFN ISSN 0022-2836PMID 21440557DOI 10.1016/J.JMB.2011.03.043 Variant Set Distributions Mapped Variants
General Structure Information 3egi TGS1 methyltransferase domain of human trimethylguanosine synthase tgs1 bound to m7gpppa (inactive form) 2.21Å AUTH T.MONECKE,A.DICKMANNS,A.STRASSER,R.FICNERTITL STRUCTURE ANALYSIS OF THE CONSERVED METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN TRIMETHYLGUANOSINE SYNTHASE TGS1.REF ACTA CRYSTALLOGR.,SECT.D V. 65 332 2009REFN ISSN 0907-4449PMID 19307714DOI 10.1107/S0907444909003102 Variant Set Distributions Mapped Variants
General Structure Information 3ow8 WDR61 crystal structure of the wd repeat-containing protein 61 2.3Å AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1 Variant Set Distributions Mapped Variants
General Structure Information 2xv4 POLR3C structure of human rpc62 (partial) 2.95Å AUTH S.LEFEVRE,H.DUMAY-ODELOT,L.EL AYOUBI,A.BUDD,P.LEGRAND,AUTH 2 N.PINAUD,M.TEICHMANN,S.FRIBOURGTITL STRUCTURE-FUNCTION ANALYSIS OF HRPC62 PROVIDES INSIGHTSTITL 2 INTO RNA POLYMERASE III TRANSCRIPTIONREF NAT.STRUCT.MOL.BIOL. V. 18 352 2011REFN ISSN 1545-9993PMID 21358628DOI 10.1038/NSMB.1996 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3omk NR1H4 crystal structure of human fxr in complex with (2s)-2-[2-(4- chlorophenyl)-5,6-difluoro-1h-benzimidazol-1-yl]-2-cyclohexyl-n-(2- methylphenyl)ethanamide 1.9Å AUTH H.G.F.RICHTER,G.M.BENSON,K.H.BLEICHER,D.BLUM,E.CHAPUT,AUTH 2 N.CLEMANN,S.FENG,C.GARDES,U.GRETHER,P.HARTMAN,B.KUHN,AUTH 3 R.E.MARTIN,J.M.PLANCHER,M.G.RUDOLPH,F.SCHULER,S.TAYLORTITL OPTIMIZATION OF A NOVEL CLASS OF BENZIMIDAZOLE-BASEDTITL 2 FARNESOID X RECEPTOR (FXR) AGONISTS TO IMPROVETITL 3 PHYSICOCHEMICAL AND ADME PROPERTIESREF BIOORG.MED.CHEM.LETT. V. 21 1134 2011REFN ISSN 0960-894XPMID 21269824DOI 10.1016/J.BMCL.2010.12.123 Variant Set Distributions […]
General Structure Information 3emw SPSB2 crystal structure of human spla/ryanodine receptor domain and socs box containing 2 (spsb2) in complex with a 20-residue vasa peptide 1.8Å AUTH P.FILIPPAKOPOULOS,A.LOW,T.D.SHARPE,J.UPPENBERG,S.YAO,AUTH 2 Z.KUANG,P.SAVITSKY,R.S.LEWIS,S.E.NICHOLSON,R.S.NORTON,AUTH 3 A.N.BULLOCKTITL STRUCTURAL BASIS FOR PAR-4 RECOGNITION BY THE SPRY DOMAIN-TITL 2 AND SOCS BOX-CONTAINING PROTEINS SPSB1, SPSB2, AND SPSB4.REF J.MOL.BIOL. V. 401 389 2010REFN […]