Assessment of Structural Intolerance and Durability
General Structure Information 6PAX PAX6 crystal structure of the human pax-6 paired domain-dna complex reveals a general model for pax protein-dna interactions 2.5Å AUTH H.E.XU,M.A.ROULD,W.XU,J.A.EPSTEIN,R.L.MAAS,C.O.PABOTITL CRYSTAL STRUCTURE OF THE HUMAN PAX6 PAIREDTITL 2 DOMAIN-DNA COMPLEX REVEALS SPECIFIC ROLES FOR THETITL 3 LINKER REGION AND CARBOXY-TERMINAL SUBDOMAIN INTITL 4 DNA BINDING.REF GENES DEV. V. 13 1263 […]
General Structure Information 2rje L3MBTL1 crystal structure of l3mbtl1 in complex with h4k20me2 (residues 17- 25), orthorhombic form ii 1.86Å AUTH J.MIN,A.ALLALI-HASSANI,N.NADY,C.QI,H.OUYANG,Y.LIU,AUTH 2 F.MACKENZIE,M.VEDADI,C.H.ARROWSMITHTITL L3MBTL1 RECOGNITION OF MONO- AND DIMETHYLATED HISTONES.REF NAT.STRUCT.MOL.BIOL. V. 14 1229 2007REFN ISSN 1545-9993PMID 18026117DOI 10.1038/NSMB1340 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vyt SCML2 the mbt repeats of human scml2 bind to peptides containing mono methylated lysine. 1.9Å AUTH C.M.SANTIVERI,B.C.LECHTENBERG,M.D.ALLEN,AUTH 2 A.SATHYAMURTHY,A.M.JAULENT,S.M.V.FREUND,M.BYCROFTTITL THE MALIGNANT BRAIN TUMOR REPEATS OF HUMAN SCML2TITL 2 BIND TO PEPTIDES CONTAINING MONOMETHYLATED LYSINE.REF J.MOL.BIOL. V. 382 1107 2008REFN ISSN 0022-2836PMID 18706910DOI 10.1016/J.JMB.2008.07.081 Variant Set Distributions Mapped Variants
General Structure Information 2q8k PA2G4 the crystal structure of ebp1 1.6Å AUTH E.KOWALINSKI,G.BANGE,B.BRADATSCH,E.HURT,K.WILD,I.SINNINGTITL THE CRYSTAL STRUCTURE OF EBP1 REVEALS A METHIONINETITL 2 AMINOPEPTIDASE FOLD AS BINDING PLATFORM FOR MULTIPLETITL 3 INTERACTIONS.REF FEBS LETT. V. 581 4450 2007REFN ISSN 0014-5793PMID 17765895DOI 10.1016/J.FEBSLET.2007.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3nau ZHX2 crystal structure of zhx2 hd2 (zinc-fingers and homeoboxes protein 2, homeodomain 2) 2.7Å AUTH L.E.BIRD,J.REN,J.E.NETTLESHIP,G.E.FOLKERS,R.J.OWENS,AUTH 2 D.K.STAMMERSTITL NOVEL STRUCTURAL FEATURES IN TWO ZHX HOMEODOMAINS DERIVEDTITL 2 FROM A SYSTEMATIC STUDY OF SINGLE AND MULTIPLE DOMAINSREF BMC STRUCT.BIOL. V. 10 13 2010REFN ESSN 1472-6807PMID 20509910DOI 10.1186/1472-6807-10-13 Variant Set Distributions Mapped Variants
General Structure Information 2eoc PARP3 solution structure of the wgr domain from human poly [adp- ribose] polymerase-3 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE WGR DOMAIN FROM HUMANTITL 2 POLY [ADP-RIBOSE] POLYMERASE-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cxk CAMTA1 crystal structure of the tig domain of human calmodulin- binding transcription activator 1 (camta1) 1.85Å AUTH A.A.PIOSZAK,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE TIG DOMAIN OF HUMANTITL 2 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1TITL 3 (CAMTA1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eoo ZKSCAN5 solution structure of the c2h2 type zinc finger (region 425- 457) of human zinc finger protein 95 homolog -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 425-457) OF HUMAN ZINC FINGER PROTEIN 95TITL 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1kbh NCOA3 mutual synergistic folding in the interaction between nuclear receptor coactivators cbp and actr -1.0Å AUTH S.J.DEMAREST,M.MARTINEZ-YAMOUT,J.CHUNG,H.CHEN,W.XU,AUTH 2 H.J.DYSON,R.M.EVANS,P.E.WRIGHTTITL MUTUAL SYNERGISTIC FOLDING IN RECRUITMENT OFTITL 2 CBP/P300 BY P160 NUCLEAR RECEPTOR COACTIVATORS.REF NATURE V. 415 549 2002REFN ISSN 0028-0836PMID 11823864DOI 10.1038/415549A Variant Set Distributions Mapped Variants
General Structure Information 3d9i SCAF8 snapshots of the rna processing factor scaf8 bound to different phosphorylated forms of the carboxy-terminal domain of rna-polymerase ii 1.91Å AUTH R.BECKER,B.LOLL,A.MEINHARTTITL SNAPSHOTS OF THE RNA PROCESSING FACTOR SCAF8 BOUND TOTITL 2 DIFFERENT PHOSPHORYLATED FORMS OF THE CARBOXYL-TERMINALTITL 3 DOMAIN OF RNA POLYMERASE II.REF J.BIOL.CHEM. V. 283 22659 2008REFN ISSN […]