Assessment of Structural Intolerance and Durability
General Structure Information 3dal PRDM1 methyltransferase domain of human pr domain-containing protein 1 1.65Å AUTH H.ZENG,M.F.AMAYA,T.ANTOSHENKO,A.DONG,P.LOPPNAU,AUTH 2 A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k1p ZRANB2 solution structure of the second zinc finger domain of zranb2/znf265 -1.0Å AUTH F.E.LOUGHLIN,R.E.MANSFIELD,P.M.VAZ,W.LEUNG,AUTH 2 S.SETIYAPUTRA,R.P.GRANT,E.S.CHEN,R.GAMSJAEGER,AUTH 3 J.P.MACKAYTITL THE ZINC FINGERS OF THE SR-PROEIN ZRANB2 RECOGNIZETITL 2 5SPLICE SITE-LIKE SEQUENCES AND CONSTITUTE ATITL 3 DISTINCT CLASS OF RNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4c0d CNOT3 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Mapped Variants
General Structure Information 1n0z ZRANB2 solution structure of the first zinc-finger domain from znf265 -1.0Å AUTH C.A.PLAMBECK,A.H.Y.KWAN,D.J.ADAMS,B.J.WESTMAN,AUTH 2 L.VAN DER WEYDEN,R.L.MEDCALF,B.J.MORRIS,J.P.MACKAYTITL THE STRUCTURE OF THE ZINC FINGER DOMAIN FROM HUMANTITL 2 SPLICING FACTOR ZNF265 FOLDREF J.BIOL.CHEM. V. 278 22805 2003REFN ISSN 0021-9258PMID 12657633DOI 10.1074/JBC.M301896200 Variant Set Distributions Mapped Variants
General Structure Information 2yqi HMGB3 solution structure of the second hmg-box domain from high mobility group protein b3 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND HMG-BOX DOMAINTITL 2 FROM HIGH MOBILITY GROUP PROTEIN B3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3h7h SUPT5H crystal structure of the human transcription elongation factor dsif, hspt4/hspt5 (176-273) 1.55Å AUTH S.WENZEL,B.M.MARTINS,P.ROSCH,B.M.WOHRLTITL CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION ELONGATIONTITL 2 FACTOR DSIF HSPT4 SUBUNIT IN COMPLEX WITH THE HSPT5TITL 3 DIMERIZATION INTERFACEREF BIOCHEM.J. V. 425 373 2010REFN ISSN 0264-6021PMID 19860741DOI 10.1042/BJ20091422 Variant Set Distributions Mapped Variants
General Structure Information 4gmj CNOT1 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 2p6v TAF4 structure of tafh domain of the human taf4 subunit of tfiid 2.0Å AUTH X.WANG,D.M.TRUCKSES,S.TAKADA,T.MATSUMURA,N.TANESE,AUTH 2 R.H.JACOBSONTITL CONSERVED REGION I OF HUMAN COACTIVATOR TAF4 BINDSTITL 2 TO A SHORT HYDROPHOBIC MOTIF PRESENT INTITL 3 TRANSCRIPTIONAL REGULATORS.REF PROC.NATL.ACAD.SCI.USA V. 104 7839 2007REFN ISSN 0027-8424PMID 17483474DOI 10.1073/PNAS.0608570104 Variant Set Distributions Mapped Variants
General Structure Information 1x2l CUX2 solution structure of the cut domain of human homeobox protein cux-2 (cut-like 2) -1.0Å AUTH Y.O.KAMATARI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CUT DOMAIN OF HUMANTITL 2 HOMEOBOX PROTEIN CUX-2 (CUT-LIKE 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hfh TCERG1 crystal structure of tandem ff domains 2.7Å AUTH M.LU,J.YANG,Z.REN,S.SABUI,A.ESPEJO,M.T.BEDFORD,AUTH 2 R.H.JACOBSON,D.JERUZALMI,J.S.MCMURRAY,X.CHENTITL CRYSTAL STRUCTURE OF THE THREE TANDEM FF DOMAINS OFTITL 2 THE TRANSCRIPTION ELONGATION REGULATOR CA150.REF J.MOL.BIOL. V. 393 397 2009REFN ISSN 0022-2836PMID 19660470DOI 10.1016/J.JMB.2009.07.086 Variant Set Distributions Mapped Variants