Assessment of Structural Intolerance and Durability
General Structure Information 4fqg TCERG1 crystal structure of the tcerg1 ff4-6 tandem repeat domain 2.0Å AUTH J.LIU,S.FAN,C.J.LEE,A.L.GREENLEAF,P.ZHOUTITL SPECIFIC INTERACTION OF THE TRANSCRIPTION ELONGATIONTITL 2 REGULATOR TCERG1 WITH RNA POLYMERASE II REQUIRESTITL 3 SIMULTANEOUS PHOSPHORYLATION AT SER2, SER5, AND SER7 WITHINTITL 4 THE CARBOXYL-TERMINAL DOMAIN REPEAT.REF J.BIOL.CHEM. V. 288 10890 2013REFN ISSN 0021-9258PMID 23436654DOI 10.1074/JBC.M113.460238 Variant […]
General Structure Information 2do3 SUPT5H solution structure of the third kow motif of transcription elongation factor spt5 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD KOW MOTIF OFTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kkr ATXN7 solution structure of sca7 zinc finger domain from human ataxin-7 protein -1.0Å AUTH J.BONNET,Y.WANG,A.ATKINSON,J.KOFFLER,C.ROMIER,A.HAMICHE,AUTH 2 L.TORA,D.DEVYS,B.KIEFFERTITL HISTONE DEUBIQUITINATION BY SAGA IS MODULATED BY ANTITL 2 ATYPICAL ZINC FINGER DOMAIN OF ATAXIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wh8 CUX2 solution structure of the third cut domain of human homeobox protein cux-2 -1.0Å AUTH N.NAMEKI,N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD CUT DOMAIN OFTITL 2 HUMAN HOMEOBOX PROTEIN CUX-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a69 HDAC3 structure of hdac3 bound to corepressor and inositol tetraphosphate 2.06Å AUTH P.J.WATSON,L.FAIRALL,G.M.SANTOS,J.W.R.SCHWABETITL STRUCTURE OF HDAC3 BOUND TO CO-REPRESSOR AND INOSITOLTITL 2 TETRAPHOSPHATE.REF NATURE V. 481 335 2012REFN ISSN 0028-0836PMID 22230954DOI 10.1038/NATURE10728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants
General Structure Information 2e70 SUPT5H solution structure of the fifth kow motif of human transcription elongation factor spt5 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH KOW MOTIF OF HUMANTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c35 POLR2D subunits rpb4 and rpb7 of human rna polymerase ii 2.7Å AUTH H.MEKA,F.WERNER,S.C.CORDELL,S.ONESTI,P.BRICKTITL CRYSTAL STRUCTURE AND RNA BINDING OF THE RPB4/RPB7TITL 2 SUBUNITS OF HUMAN RNA POLYMERASE II.REF NUCLEIC ACIDS RES. V. 33 6435 2005REFN ISSN 0305-1048PMID 16282592DOI 10.1093/NAR/GKI945 Variant Set Distributions Mapped Variants
General Structure Information 3geb EYA2 crystal structure of edeya2 2.4Å AUTH S.J.KIM,D.G.JEONG,S.K.JUNG,E.R.SEONGTITL STRUCTURE OF EDEYA2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yok NR5A2 crystal structure of human lrh-1 bound with tif-2 peptide and phosphatidylglycerol 2.5Å AUTH I.N.KRYLOVA,E.P.SABLIN,J.MOORE,R.X.XU,G.M.WAITT,AUTH 2 J.A.MACKAY,D.JUZUMIENE,J.M.BYNUM,K.MADAUSS,AUTH 3 V.MONTANA,L.LEBEDEVA,M.SUZAWA,J.D.WILLIAMS,AUTH 4 S.P.WILLIAMS,R.K.GUY,J.W.THORNTON,R.J.FLETTERICK,AUTH 5 T.M.WILLSON,H.A.INGRAHAMTITL STRUCTURAL ANALYSES REVEAL PHOSPHATIDYL INOSITOLSTITL 2 AS LIGANDS FOR THE NR5 ORPHAN RECEPTORS SF-1 ANDTITL 3 LRH-1.REF CELL(CAMBRIDGE,MASS.) V. 120 343 2005REFN ISSN 0092-8674PMID 15707893DOI 10.1016/J.CELL.2005.01.024 Variant Set […]