Assessment of Structural Intolerance and Durability
General Structure Information 2ctl HDLBP solution structure of the 13th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 13TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cte HDLBP solution structure of the 1st kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ctm HDLBP solution structure of the 14th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gd8 AQP4 crystal structure of human aquaporin 4 at 1.8 and its mechanism of conductance 1.8Å AUTH J.D.HO,R.YEH,A.SANDSTROM,I.CHORNY,W.E.HARRIES,R.A.ROBBINS,AUTH 2 L.J.MIERCKE,R.M.STROUDTITL CRYSTAL STRUCTURE OF HUMAN AQUAPORIN 4 AT 1.8 A AND ITSTITL 2 MECHANISM OF CONDUCTANCE.REF PROC.NATL.ACAD.SCI.USA V. 106 7437 2009REFN ISSN 0027-8424PMID 19383790DOI 10.1073/PNAS.0902725106 Variant Set Distributions Mapped Variants
General Structure Information 2bba EPHB4 crystal structure and thermodynamic characterization of the ephb4 receptor in complex with an ephrin-b2 antagonist peptide reveals the determinants for receptor specificity. 1.65Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,M.L.KRAUS,M.KOOLPE,AUTH 2 A.R.KOLATKAR,R.H.BRUCE,G.MARTINY-BARON,H.WIDMER,AUTH 3 E.B.PASQUALE,P.KUHNTITL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THETITL 2 EPHB4/EPHRIN-B2 ANTAGONIST PEPTIDE COMPLEX REVEALS THETITL 3 DETERMINANTS FOR RECEPTOR SPECIFICITY.REF STRUCTURE V. 14 […]
General Structure Information 1wao PPP5C pp5 structure 2.9Å AUTH J.YANG,S.M.ROE,M.J.CLIFF,M.A.WILLIAMS,J.E.LADBURY,AUTH 2 P.T.COHEN,D.BARFORDTITL MOLECULAR BASIS FOR TPR DOMAIN-MEDIATED REGULATIONTITL 2 OF PROTEIN PHOSPHATASE 5REF EMBO J. V. 24 1 2005REFN ISSN 0261-4189PMID 15577939DOI 10.1038/SJ.EMBOJ.7600496 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1pve RAD23B solution structure of xpc binding domain of hhr23b -1.0Å AUTH B.KIM,K.S.RYU,H.J.KIM,S.J.CHO,B.S.CHOITITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 XPC-BINDING DOMAIN OF THE HUMAN DNA REPAIR PROTEINTITL 3 HHR23B.REF FEBS J. V. 272 2467 2005REFN ISSN 1742-464XPMID 15885096DOI 10.1111/J.1742-4658.2005.04667.X Variant Set Distributions Mapped Variants
General Structure Information 2hle EFNB2 structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity. 2.05Å AUTH J.E.CHRENCIK,A.BROOUN,M.L.KRAUS,M.I.RECHT,A.R.KOLATKAR,AUTH 2 G.W.HAN,J.M.SEIFERT,H.WIDMER,M.AUER,P.KUHNTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THETITL 2 EPHB4-EPHRINB2 PROTEIN-PROTEIN INTERACTION AND RECEPTORTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 281 28185 2006REFN ISSN 0021-9258PMID 16867992DOI 10.1074/JBC.M605766200 Variant Set Distributions Mapped Variants
General Structure Information 2le3 CPT1A n-terminal regulatory segment of carnitine palmitoyltransferase 1a -1.0Å AUTH J.N.RAO,G.Z.WARREN,S.ESTOLT-POVEDANO,V.A.ZAMMIT,T.S.ULMERTITL AN ENVIRONMENT-DEPENDENT STRUCTURAL SWITCH UNDERLIES THETITL 2 REGULATION OF CARNITINE PALMITOYLTRANSFERASE 1A.REF J.BIOL.CHEM. V. 286 42545 2011REFN ISSN 0021-9258PMID 21990363DOI 10.1074/JBC.M111.306951 Variant Set Distributions Mapped Variants
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants