Assessment of Structural Intolerance and Durability
General Structure Information 2d2z CLIC4 crystal structure of soluble form of clic4 2.2Å AUTH Y.F.LI,D.F.LI,Z.H.ZENG,D.C.WANGTITL TRIMERIC STRUCTURE OF THE WILD SOLUBLE CHLORIDETITL 2 INTRACELLULAR ION CHANNEL CLIC4 OBSERVED INTITL 3 CRYSTALSREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 343 1272 2006REFN ISSN 0006-291XPMID 16581025DOI 10.1016/J.BBRC.2006.03.099 Variant Set Distributions Mapped Variants
General Structure Information 2mj7 AP4B1 solution nmr structure of beta-adaptin appendage domain of human adaptor protein complex 4 subunit beta, northeast structural genomics consortium (nesg) target hr8998c -1.0Å AUTH A.ELETSKY,D.J.ROTSHTEYN,K.PEDERSON,R.SHASTRY,M.MAGLAQUI,AUTH 2 H.JANJUA,R.XIAO,J.K.EVERETT,G.T.MONTELIONE,J.H.PRESTEGARD,AUTH 3 T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF BETA-ADAPTIN APPENDAGE DOMAIN OFTITL 2 HUMAN ADAPTOR PROTEIN COMPLEX 4 SUBUNIT BETA, NORTHEASTTITL 3 STRUCTURAL GENOMICS CONSORTIUM […]
General Structure Information 3ihr UCHL5 crystal structure of uch37 2.95Å AUTH S.E.BURGIE,C.A.BINGMAN,A.B.SONI,G.N.PHILLIPSTITL STRUCTURAL CHARACTERIZATION OF HUMAN UCH37.REF PROTEINS 2011REFN ESSN 1097-0134PMID 21953935DOI 10.1002/PROT.23147 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l8n ARFGEF2 crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id hr5562a 2.86Å AUTH J.SEETHARAMAN,M.SU,F.FOROUHAR,D.WANG,H.JANJUA,AUTH 2 K.CUNNINGHAM,L.OWENS,R.XIAO,J.LIU,M.C.BARAN,AUTH 3 T.B.ACTON,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL CRYSTAL STRUCTURE OF A DOMAIN OF BREFELDINTITL 2 A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2TITL 3 (BREFELDINA-INHIBITED GEP 2) […]
General Structure Information 3bd0 MEMO1 crystal structure of memo, form ii 3.01Å AUTH C.QIU,S.LIENHARD,N.E.HYNES,A.BADACHE,D.J.LEAHYTITL MEMO IS HOMOLOGOUS TO NONHEME IRON DIOXYGENASESTITL 2 AND BINDS AN ERBB2-DERIVED PHOSPHOPEPTIDE IN ITSTITL 3 VESTIGIAL ACTIVE SITE.REF J.BIOL.CHEM. V. 283 2734 2008REFN ISSN 0021-9258PMID 18045866DOI 10.1074/JBC.M703523200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lgr OARD1 solution structure of human protein c6orf130, a putative macro domain -1.0Å AUTH F.C.PETERSON,D.CHEN,B.L.LYTLE,M.N.ROSSI,I.AHEL,J.M.DENU,AUTH 2 B.F.VOLKMANTITL ORPHAN MACRODOMAIN PROTEIN (HUMAN C6ORF130) IS ANTITL 2 O-ACYL-ADP-RIBOSE DEACYLASE: SOLUTION STRUCTURE ANDTITL 3 CATALYTIC PROPERTIES.REF J.BIOL.CHEM. V. 286 35955 2011REFN ISSN 0021-9258PMID 21849506DOI 10.1074/JBC.M111.276238 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1tvg HSPB11 x-ray structure of human pp25 gene product, hspc034. northeast structural genomics target hr1958. 1.6Å AUTH T.A.RAMELOT,S.RAMAN,A.P.KUZIN,R.XIAO,L.C.MA,AUTH 2 T.B.ACTON,J.F.HUNT,G.T.MONTELIONE,D.BAKER,AUTH 3 M.A.KENNEDYTITL IMPROVING NMR PROTEIN STRUCTURE QUALITY BY ROSETTATITL 2 REFINEMENT: A MOLECULAR REPLACEMENT STUDY.REF PROTEINS V. 75 147 2009REFN ISSN 0887-3585PMID 18816799DOI 10.1002/PROT.22229 Variant Set Distributions Mapped Variants
General Structure Information 2m9x MAST1 solution nmr structure of microtubule-associated serine/threonine- protein kinase 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr9151a -1.0Å AUTH X.XU,A.ELETSKY,R.SHASTRY,D.LEE,K.HAMILTON,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF MICROTUBULE-ASSOCIATEDTITL 2 SERINE/THREONINE-PROTEIN KINASE 1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR9151AREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2lna AFG3L2 solution nmr structure of the mitochondrial inner membrane domain (residues 164-251), ftsh_ext, from the paraplegin-like protein afg3l2 from homo sapiens, northeast structural genomics consortium target hr6741a -1.0Å AUTH T.A.RAMELOT,Y.YANG,I.D.SAHU,H.W.LEE,R.XIAO,G.A.LORIGAN,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE AND MD SIMULATIONS OF THE AAA PROTEASETITL 2 INTERMEMBRANE SPACE DOMAIN INDICATES PERIPHERAL MEMBRANETITL 3 LOCALIZATION WITHIN […]
General Structure Information 3evx UFC1 crystal structure of the human e2-like ubiquitin-fold modifier conjugating enzyme 1 (ufc1). northeast structural genomics consortium target hr41 2.54Å AUTH G.LIU,F.FOROUHAR,A.ELETSKY,H.S.ATREYA,J.M.ARAMINI,AUTH 2 R.XIAO,Y.J.HUANG,M.ABASHIDZE,J.SEETHARAMAN,J.LIU,AUTH 3 B.ROST,T.ACTON,G.T.MONTELIONE,J.F.HUNT,T.SZYPERSKITITL NMR AND X-RAY STRUCTURES OF HUMAN E2-LIKETITL 2 UBIQUITIN-FOLD MODIFIER CONJUGATING ENZYME 1TITL 3 (UFC1) REVEAL STRUCTURAL AND FUNCTIONALTITL 4 CONSERVATION IN THE METAZOAN UFM1-UBA5-UFC1TITL […]