Assessment of Structural Intolerance and Durability
General Structure Information 2l33 ILF3 solution nmr structure of drbm 2 domain of interleukin enhancer- binding factor 3 from homo sapiens, northeast structural genomics consortium target hr4527e -1.0Å AUTH G.LIU,H.JANJUA,R.XIAO,T.B.ACTON,J.EVERETT,G.T.MONTELIONETITL NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4527EREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k27 PAX8 solution structure of human pax8 paired box domain -1.0Å AUTH L.CODUTTI,H.VAN INGEN,C.VASCOTTO,F.FOGOLARI,AUTH 2 A.CORAZZA,G.TELL,F.QUADRIFOGLIO,P.VIGLINO,AUTH 3 R.BOELENS,G.ESPOSITOTITL THE SOLUTION STRUCTURE OF DNA-FREE PAX-8 PAIRED BOXTITL 2 DOMAIN ACCOUNTS FOR REDOX REGULATION OFTITL 3 TRANSCRIPTIONAL ACTIVITY IN THE PAX PROTEIN FAMILY.REF J.BIOL.CHEM. V. 283 33321 2008REFN ISSN 0021-9258PMID 18829450DOI 10.1074/JBC.M805717200 Variant Set […]
General Structure Information 2g9o ATP7A solution structure of the apo form of the third metal- binding domain of atp7a protein (menkes disease protein) -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,N.DELLAMALVA,AUTH 2 T.HERRMANN,A.ROSATO,K.WUTHRICHTITL SOLUTION STRUCTURE AND INTERMOLECULAR INTERACTIONSTITL 2 OF THE THIRD METAL-BINDING DOMAIN OF ATP7A, THETITL 3 MENKES DISEASE PROTEIN.REF J.BIOL.CHEM. V. 281 29141 2006REFN ISSN 0021-9258PMID 16873374DOI 10.1074/JBC.M603176200 […]
General Structure Information 2ge9 BTK solution structures of the sh2 domain of brutons tyrosine kinase -1.0Å AUTH K.-C.HUANG,H.-T.CHENG,M.-T.PAI,S.-R.TZENG,AUTH 2 J.-W.CHENGTITL SOLUTION STRUCTURE AND PHOSPHOPEPTIDE BINDING OFTITL 2 THE SH2 DOMAIN FROM THE HUMAN BRUTONS TYROSINETITL 3 KINASEREF J.BIOMOL.NMR V. 36 73 2006REFN ISSN 0925-2738PMID 16969585DOI 10.1007/S10858-006-9064-3 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1d5f UBE3A structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway 2.8Å AUTH L.HUANG,E.KINNUCAN,G.WANG,S.BEAUDENON,P.M.HOWLEY,AUTH 2 J.M.HUIBREGTSE,N.P.PAVLETICHTITL STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTOTITL 2 UBIQUITINATION BY THE E2-E3 ENZYME CASCADE.REF SCIENCE V. 286 1321 1999REFN ISSN 0036-8075PMID 10558980DOI 10.1126/SCIENCE.286.5443.1321 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1q1u FGF12 crystal structure of human fhf1b (fgf12b) 1.7Å AUTH S.K.OLSEN,M.GARBI,N.ZAMPIERI,A.V.ELISEENKOVA,AUTH 2 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL FIBROBLAST GROWTH FACTOR (FGF) HOMOLOGOUS FACTORSTITL 2 SHARE STRUCTURAL BUT NOT FUNCTIONAL HOMOLOGY WITHTITL 3 FGFSREF J.BIOL.CHEM. V. 278 34226 2003REFN ISSN 0021-9258PMID 12815063DOI 10.1074/JBC.M303183200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1ncv CCL7 determination cc-chemokine mcp-3, nmr, 7 structures -1.0Å AUTH S.MEUNIER,J.M.BERNASSAU,J.C.GUILLEMOT,P.FERRARA,AUTH 2 H.DARBONTITL DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURETITL 2 OF CC CHEMOKINE MONOCYTE CHEMOATTRACTANT PROTEIN 3TITL 3 BY 1H TWO-DIMENSIONAL NMR SPECTROSCOPY.REF BIOCHEMISTRY V. 36 4412 1997REFN ISSN 0006-2960PMID 9109648DOI 10.1021/BI9627929 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3oe8 CXCR4 crystal structure of the cxcr4 chemokine receptor in complex with a small molecule antagonist it1t in p1 spacegroup 3.1Å AUTH B.WU,E.Y.CHIEN,C.D.MOL,G.FENALTI,W.LIU,V.KATRITCH,R.ABAGYAN,AUTH 2 A.BROOUN,P.WELLS,F.C.BI,D.J.HAMEL,P.KUHN,T.M.HANDEL,AUTH 3 V.CHEREZOV,R.C.STEVENSTITL STRUCTURES OF THE CXCR4 CHEMOKINE GPCR WITH SMALL-MOLECULETITL 2 AND CYCLIC PEPTIDE ANTAGONISTS.REF SCIENCE V. 330 1066 2010REFN ISSN 0036-8075PMID 20929726DOI 10.1126/SCIENCE.1194396 Variant Set Distributions […]
General Structure Information 2ctj HDLBP solution structure of the 8th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 8TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants