General Structure Information
| PDB ID | 2k27 |
| HGNC Gene Label(s) | PAX8 |
| Structure Name | solution structure of human pax8 paired box domain |
| Resolution | -1.0Å |
| Reference | AUTH L.CODUTTI,H.VAN INGEN,C.VASCOTTO,F.FOGOLARI,AUTH 2 A.CORAZZA,G.TELL,F.QUADRIFOGLIO,P.VIGLINO,AUTH 3 R.BOELENS,G.ESPOSITOTITL THE SOLUTION STRUCTURE OF DNA-FREE PAX-8 PAIRED BOXTITL 2 DOMAIN ACCOUNTS FOR REDOX REGULATION OFTITL 3 TRANSCRIPTIONAL ACTIVITY IN THE PAX PROTEIN FAMILY.REF J.BIOL.CHEM. V. 283 33321 2008REFN ISSN 0021-9258PMID 18829450DOI 10.1074/JBC.M805717200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 143 |
| Number Of SNVs | 27 |
| Number Of Permutations | 32348 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.028 |
| p-value | 0.77 |
ClinVar
| Number Of Residues | 143 |
| Number Of SNVs | 6 |
| Number Of Permutations | 5065 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 1.0 |
| p-value | 0.004 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.652 |
| p-value | 0.025 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
