Assessment of Structural Intolerance and Durability
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lz1 NFE2L2 solution nmr structure of the dna-binding domain of human nf-e2- related factor 2, northeast structural genomics consortium (nesg) target hr3520o -1.0Å AUTH A.ELETSKY,S.V.S.R.K.PULAVARTI,D.LEE,E.KOHAN,H.JANJUA,R.XIAO,AUTH 2 T.B.ACTON,J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMANTITL 2 NF-E2-RELATED FACTOR 2, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3520OREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3mpx FGD5 crystal structure of the dh and ph-1 domains of human fgd5 2.8Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2yuh TBCC solution structure of the c-terminal region in human tubulin folding cofactor c -1.0Å AUTH K.SAITO,N.TOCHIO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL REGION INTITL 2 HUMAN TUBULIN FOLDING COFACTOR CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2edh OBSCN solution structure of the pdz domain (3614- 3713 ) from human obscurin -1.0Å AUTH H.ENDO,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN (3614 – 3713 ) FROMTITL 2 HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ug1 DNMBP sh3 domain of hypothetical protein baa76854.1 -1.0Å AUTH T.NAGATA,Y.MUTO,Y.KAMEWARI,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAKAYAMA,AUTH 5 S.YOKOYAMATITL NMR STRUCTURE OF SH3 DOMAIN OF HYPOTHETICALTITL 2 PROTEIN BAA76854.1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e7m KIAA0319 solution structure of the pkd domain (329-428) from human kiaa0319 -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PKD DOMAIN (329-428)TITL 2 FROM HUMAN KIAA0319REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants