Assessment of Structural Intolerance and Durability
General Structure Information 2ept ZNF32 solution structure of the first c2h2 type zinc finger domain of zinc finger protein 32 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2H2 TYPE ZINCTITL 2 FINGER DOMAIN OF ZINC FINGER PROTEIN 32REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qc8 GLUL crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate 2.6Å AUTH W.W.KRAJEWSKI,R.COLLINS,L.HOLMBERG-SCHIAVONE,T.A.JONES,AUTH 2 T.KARLBERG,S.L.MOWBRAYTITL CRYSTAL STRUCTURES OF MAMMALIAN GLUTAMINE SYNTHETASESTITL 2 ILLUSTRATE SUBSTRATE-INDUCED CONFORMATIONAL CHANGES ANDTITL 3 PROVIDE OPPORTUNITIES FOR DRUG AND HERBICIDE DESIGN.REF J.MOL.BIOL. V. 375 217 2008REFN ISSN 0022-2836PMID 18005987DOI 10.1016/J.JMB.2007.10.029 Variant Set […]
General Structure Information 2gdz HPGD crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with nad+ 1.65Å AUTH F.H.NIESEN,L.SCHULTZ,A.JADHAV,C.BHATIA,K.GUO,D.J.MALONEY,AUTH 2 E.S.PILKA,M.WANG,U.OPPERMANN,T.D.HEIGHTMAN,A.SIMEONOVTITL HIGH-AFFINITY INHIBITORS OF HUMAN NAD-DEPENDENTTITL 2 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE: MECHANISMS OFTITL 3 INHIBITION AND STRUCTURE-ACTIVITY RELATIONSHIPS.REF PLOS ONE V. 5 E1371 2010REFN ESSN 1932-6203PMID 21072165DOI 10.1371/JOURNAL.PONE.0013719 Variant Set Distributions Mapped Variants
General Structure Information 2fvl AKR1C4 crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (akr1c4) complexed with nadp+ 2.4Å AUTH E.UGOCHUKWU,C.SMEE,K.GUO,P.LUKACIK,K.KAVANAGH,AUTH 2 J.E.DEBRECZENI,F.VON DELFT,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-ALPHATITL 2 HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE (AKR1C4) COMPLEXEDTITL 3 WITH NADP+REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ror VAV1 solution structure of the vav1 sh2 domain complexed with a tyrosine-phosphorylated peptide from slp76 -1.0Å AUTH T.KASAI,M.TANAKA,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE VAV1 SH2 DOMAINTITL 2 COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDETITL 3 FROM SLP76REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dyd TAT human tyrosine aminotransferase 2.3Å AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d0u IDO1 crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase 3.4Å AUTH H.SUGIMOTO,S.ODA,T.OTSUKI,T.HINO,T.YOSHIDA,Y.SHIROTITL CRYSTAL STRUCTURE OF HUMAN INDOLEAMINETITL 2 2,3-DIOXYGENASE: CATALYTIC MECHANISM OF O2TITL 3 INCORPORATION BY A HEME-CONTAINING DIOXYGENASE.REF PROC.NATL.ACAD.SCI.USA V. 103 2611 2006REFN ISSN 0027-8424PMID 16477023DOI 10.1073/PNAS.0508996103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2o0l SRM human spermidine synthase 1.99Å AUTH H.WU,J.MIN,Y.IKEGUCHI,H.ZENG,A.DONG,P.LOPPNAU,A.E.PEGG,AUTH 2 A.N.PLOTNIKOVTITL STRUCTURE AND MECHANISM OF SPERMIDINE SYNTHASES.REF BIOCHEMISTRY V. 46 8331 2007REFN ISSN 0006-2960PMID 17585781DOI 10.1021/BI602498K Variant Set Distributions Mapped Variants
General Structure Information 3ii0 GOT1 crystal structure of human glutamate oxaloacetate transaminase 1 (got1) 2.05Å AUTH E.UGOCHUKWU,E.PILKA,C.COOPER,J.E.BRAY,W.W.YUE,J.MUNIZ,AUTH 2 A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATETITL 2 TRANSAMINASE 1 (GOT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dbf NFKB1 solution structure of the death domain in human nuclear factor nf-kappa-b p105 subunit -1.0Å AUTH K.SAITO,M.INOUE,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEATH DOMAIN IN HUMANTITL 2 NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants