General Structure Information
| PDB ID | 2fvl |
| HGNC Gene Label(s) | AKR1C4 |
| Structure Name | crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (akr1c4) complexed with nadp+ |
| Resolution | 2.4Å |
| Reference | AUTH E.UGOCHUKWU,C.SMEE,K.GUO,P.LUKACIK,K.KAVANAGH,AUTH 2 J.E.DEBRECZENI,F.VON DELFT,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-ALPHATITL 2 HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE (AKR1C4) COMPLEXEDTITL 3 WITH NADP+REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 323 |
| Number Of SNVs | 94 |
| Number Of Permutations | 40276 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.021 |
| p-value | 0.539 |
COSMIC
| Number Of Residues | 323 |
| Number Of SNVs | 13 |
| Number Of Permutations | 7618 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.128 |
| p-value | 0.124 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 94 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.085 |
| p-value | 0.288 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
