Assessment of Structural Intolerance and Durability
General Structure Information 2pqt NAT1 human n-acetyltransferase 1 1.78Å AUTH H.WU,L.DOMBROVSKY,W.TEMPEL,F.MARTIN,P.LOPPNAU,AUTH 2 G.H.GOODFELLOW,D.M.GRANT,A.N.PLOTNIKOVTITL STRUCTURAL BASIS OF SUBSTRATE-BINDING SPECIFICITYTITL 2 OF HUMAN ARYLAMINE N-ACETYLTRANSFERASES.REF J.BIOL.CHEM. V. 282 30189 2007REFN ISSN 0021-9258PMID 17656365DOI 10.1074/JBC.M704138200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qc8 GLUL crystal structure of human glutamine synthetase in complex with adp and methionine sulfoximine phosphate 2.6Å AUTH W.W.KRAJEWSKI,R.COLLINS,L.HOLMBERG-SCHIAVONE,T.A.JONES,AUTH 2 T.KARLBERG,S.L.MOWBRAYTITL CRYSTAL STRUCTURES OF MAMMALIAN GLUTAMINE SYNTHETASESTITL 2 ILLUSTRATE SUBSTRATE-INDUCED CONFORMATIONAL CHANGES ANDTITL 3 PROVIDE OPPORTUNITIES FOR DRUG AND HERBICIDE DESIGN.REF J.MOL.BIOL. V. 375 217 2008REFN ISSN 0022-2836PMID 18005987DOI 10.1016/J.JMB.2007.10.029 Variant Set […]
General Structure Information 2gdz HPGD crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with nad+ 1.65Å AUTH F.H.NIESEN,L.SCHULTZ,A.JADHAV,C.BHATIA,K.GUO,D.J.MALONEY,AUTH 2 E.S.PILKA,M.WANG,U.OPPERMANN,T.D.HEIGHTMAN,A.SIMEONOVTITL HIGH-AFFINITY INHIBITORS OF HUMAN NAD-DEPENDENTTITL 2 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE: MECHANISMS OFTITL 3 INHIBITION AND STRUCTURE-ACTIVITY RELATIONSHIPS.REF PLOS ONE V. 5 E1371 2010REFN ESSN 1932-6203PMID 21072165DOI 10.1371/JOURNAL.PONE.0013719 Variant Set Distributions Mapped Variants
General Structure Information 2fvl AKR1C4 crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (akr1c4) complexed with nadp+ 2.4Å AUTH E.UGOCHUKWU,C.SMEE,K.GUO,P.LUKACIK,K.KAVANAGH,AUTH 2 J.E.DEBRECZENI,F.VON DELFT,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-ALPHATITL 2 HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE (AKR1C4) COMPLEXEDTITL 3 WITH NADP+REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dz8 RAB3B crystal structure of human rab3b gtpase bound with gdp 1.9Å AUTH Y.SHEN,Y.TONG,D.SUKUMAR,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB3B GTPASE BOUND WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dyd TAT human tyrosine aminotransferase 2.3Å AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o0l SRM human spermidine synthase 1.99Å AUTH H.WU,J.MIN,Y.IKEGUCHI,H.ZENG,A.DONG,P.LOPPNAU,A.E.PEGG,AUTH 2 A.N.PLOTNIKOVTITL STRUCTURE AND MECHANISM OF SPERMIDINE SYNTHASES.REF BIOCHEMISTRY V. 46 8331 2007REFN ISSN 0006-2960PMID 17585781DOI 10.1021/BI602498K Variant Set Distributions Mapped Variants
General Structure Information 3ii0 GOT1 crystal structure of human glutamate oxaloacetate transaminase 1 (got1) 2.05Å AUTH E.UGOCHUKWU,E.PILKA,C.COOPER,J.E.BRAY,W.W.YUE,J.MUNIZ,AUTH 2 A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATETITL 2 TRANSAMINASE 1 (GOT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2he3 GPX2 crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (gpx2) 2.1Å AUTH K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO CYSTEINE MUTANTTITL 2 OF HUMAN GLUTATHIONINE PEROXIDASE 2 (GPX2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fe1 HSPA6 crystal structure of the human 70kda heat shock protein 6 (hsp70b) atpase domain in complex with adp and inorganic phosphate 2.2Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,AUTH 2 T.KOTENYOVA,M.MOCHE,H.SCHUELERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOURTITL 2 HUMAN HSP70 ISOFORMS: HSPA1L/HSP70-HOM,TITL 3 HSPA2/HSP70-2, HSPA6/HSP70B, AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN […]