Assessment of Structural Intolerance and Durability
General Structure Information 2r2j ERP44 crystal structure of human erp44 2.6Å AUTH L.K.WANG,L.WANG,S.VAVASSORI,S.J.LI,H.KE,T.ANELLI,M.DEGANO,AUTH 2 R.RONZONI,R.SITIA,F.SUN,C.C.WANGTITL CRYSTAL STRUCTURE OF HUMAN ERP44 SHOWS A DYNAMIC FUNCTIONALTITL 2 MODULATION BY ITS CARBOXY-TERMINAL TAIL.REF EMBO REP. 2008REFN ESSN 1469-3178PMID 18552768DOI 10.1038/EMBOR.2008.88 Variant Set Distributions Mapped Variants
General Structure Information 3fzm BAG1 crystal structures of hsc70/bag1 in complex with small molecule inhibitors 2.3Å AUTH D.S.WILLIAMSON,J.BORGOGNONI,A.CLAY,Z.DANIELS,AUTH 2 P.DOKURNO,M.J.DRYSDALE,N.FOLOPPE,G.L.FRANCIS,AUTH 3 C.J.GRAHAM,R.HOWES,A.T.MACIAS,J.B.MURRAY,R.PARSONS,AUTH 4 T.SHAW,A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,AUTH 5 A.J.MASSEYTITL NOVEL ADENOSINE-DERIVED INHIBITORS OF 70 KDA HEATTITL 2 SHOCK PROTEIN, DISCOVERED THROUGH STRUCTURE-BASEDTITL 3 DESIGNREF J.MED.CHEM. V. 52 1510 2009REFN ISSN 0022-2623PMID 19256508DOI 10.1021/JM801627A Variant Set Distributions Ripley’s K […]
General Structure Information 3ecs EIF2B1 crystal structure of human eif2b alpha 2.65Å AUTH T.B.HIYAMA,T.ITO,H.IMATAKA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN TRANSLATIONTITL 2 INITIATION FACTOR 2BREF J.MOL.BIOL. V. 392 937 2009REFN ISSN 0022-2836PMID 19631657DOI 10.1016/J.JMB.2009.07.054 Variant Set Distributions Mapped Variants
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants